Tenofovir alafenamide nephrotoxicity in an HIV-positive patient

Tessa K. Novick, Michael J. Choi, Avi Z. Rosenberg, Blaithin A. McMahon, Derek Fine, Mohamed G. Atta

Research output: Contribution to journalArticlepeer-review

Abstract

Rationale: Tenofovir alafenamide (TAF) is novel prodrug of Tenofovir, a nucleotide reverse transcriptase inhibitor. TAF is less nephrotoxic than its predecessor prodrug, tenofovir disoproxil fumarate (TDF). Tenofovir causes mitochondrial dysfunction and tubular injury when there is elevated accumulation in proximal tubule cells. TAF's unique pharmacokinetic profile enables provision of lower required doses for antiviral efficacy. Lower concentrations reach renal tubules minimizing intracellular accumulation and mitochondrial damage. TAF has not been associated with the histologic markers of tenofovir-associated nephrotoxicity that are seen with TDF, such as dysmorphic mitochondria in proximal tubule cells. Here, we report a patient with dysmorphic mitochondria on kidney biopsy after initiating therapy with TAF. Lessons: This case suggests that at risk individuals may experience tubular mitochondrial injury from lower concentrations of tenofovir with TAF.

Original languageEnglish (US)
Article numbere8046
JournalMedicine (United States)
Volume96
Issue number36
DOIs
StatePublished - Sep 1 2017

Keywords

  • HIV
  • proximal tubule injury
  • tenofovir alafenamide
  • tenofovir nephrotoxicity

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Tenofovir alafenamide nephrotoxicity in an HIV-positive patient'. Together they form a unique fingerprint.

Cite this