Tenascin in meningioma

Expression is correlated with anaplasia, vascular endothelial growth factor expression, and peritumoral edema but not with tumor border shape

Türker Kiliç, Yaşar Bayri, Koray Özduman, Melih Acar, Semin Diren, Özlem Kurtkaya, Gazanfer Ekinci, Kuyaş Buǧra, Aydin Sav, M. Memet Özek, M. Necmettin Pamir, Joseph M. Piepmeier, Maciej S. Lesniak, Henry Brem, Andrew H. Kaye, James T. Rutka

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Tenascin is an extracellular matrix glycoprotein that is expressed during embryogenesis, inflammation, angiogenesis, and carcinogenesis. The aim of this study was to investigate how tenascin expression relates to histological grade, angiogenesis, and radiological findings in meningiomas. METHODS: Twenty typical, 20 atypical, and 5 malignant meningiomas were studied retrospectively. Tenascin expression and vascular endothelial growth factor (VEGF) expression in the tumor tissue were investigated by immunohistochemistry. Tenascin messenger ribonucleic acid expression was also studied by comparative reverse transcriptase-polymerase chain reaction. Magnetic resonance images from each case were assessed for peritumoral edema and tumor border shape. RESULTS: The atypical and malignant meningiomas showed higher levels of tenascin expression than the typical meningiomas. The more sensitive messenger ribonucleic acid-based methods confirmed this finding. Tenascin expression was correlated with peritumoral edema and VEGF expression but not with tumor border shape. In the 13 tumors with marked tenascin expression, peritumoral edema was Grade 0 in one, Grade 1 in three, and Grade 2 in nine specimens. In the same 13 tumors, VEGF expression was Grade 1 in five and Grade 2 in eight specimens, and the findings for tumor border shape were Grade 0 in seven, Grade 1 in four, and Grade 2 in two specimens. CONCLUSION: In meningiomas, tenascin expression is correlated with anaplasia, tumor-associated edema, and VEGF expression but not with tumor border shape. This protein may play a role in the neoplastic and/or angiogenic processes in atypical and malignant meningiomas and may thus be a potential target for meningioma therapy.

Original languageEnglish (US)
Pages (from-to)183-193
Number of pages11
JournalNeurosurgery
Volume51
Issue number1
DOIs
StatePublished - Jul 1 2002
Externally publishedYes

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Anaplasia
Tenascin
Meningioma
Vascular Endothelial Growth Factor A
Edema
Neoplasms
RNA
Reverse Transcriptase Polymerase Chain Reaction
Embryonic Development
Extracellular Matrix
Glycoproteins
Carcinogenesis
Magnetic Resonance Spectroscopy
Immunohistochemistry
Inflammation

Keywords

  • Angiogenesis
  • Extracellular matrix
  • Meningioma
  • Peritumoral edema
  • Tenascin

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Tenascin in meningioma : Expression is correlated with anaplasia, vascular endothelial growth factor expression, and peritumoral edema but not with tumor border shape. / Kiliç, Türker; Bayri, Yaşar; Özduman, Koray; Acar, Melih; Diren, Semin; Kurtkaya, Özlem; Ekinci, Gazanfer; Buǧra, Kuyaş; Sav, Aydin; Memet Özek, M.; Necmettin Pamir, M.; Piepmeier, Joseph M.; Lesniak, Maciej S.; Brem, Henry; Kaye, Andrew H.; Rutka, James T.

In: Neurosurgery, Vol. 51, No. 1, 01.07.2002, p. 183-193.

Research output: Contribution to journalArticle

Kiliç, T, Bayri, Y, Özduman, K, Acar, M, Diren, S, Kurtkaya, Ö, Ekinci, G, Buǧra, K, Sav, A, Memet Özek, M, Necmettin Pamir, M, Piepmeier, JM, Lesniak, MS, Brem, H, Kaye, AH & Rutka, JT 2002, 'Tenascin in meningioma: Expression is correlated with anaplasia, vascular endothelial growth factor expression, and peritumoral edema but not with tumor border shape', Neurosurgery, vol. 51, no. 1, pp. 183-193. https://doi.org/10.1097/00006123-200207000-00026
Kiliç, Türker ; Bayri, Yaşar ; Özduman, Koray ; Acar, Melih ; Diren, Semin ; Kurtkaya, Özlem ; Ekinci, Gazanfer ; Buǧra, Kuyaş ; Sav, Aydin ; Memet Özek, M. ; Necmettin Pamir, M. ; Piepmeier, Joseph M. ; Lesniak, Maciej S. ; Brem, Henry ; Kaye, Andrew H. ; Rutka, James T. / Tenascin in meningioma : Expression is correlated with anaplasia, vascular endothelial growth factor expression, and peritumoral edema but not with tumor border shape. In: Neurosurgery. 2002 ; Vol. 51, No. 1. pp. 183-193.
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abstract = "OBJECTIVE: Tenascin is an extracellular matrix glycoprotein that is expressed during embryogenesis, inflammation, angiogenesis, and carcinogenesis. The aim of this study was to investigate how tenascin expression relates to histological grade, angiogenesis, and radiological findings in meningiomas. METHODS: Twenty typical, 20 atypical, and 5 malignant meningiomas were studied retrospectively. Tenascin expression and vascular endothelial growth factor (VEGF) expression in the tumor tissue were investigated by immunohistochemistry. Tenascin messenger ribonucleic acid expression was also studied by comparative reverse transcriptase-polymerase chain reaction. Magnetic resonance images from each case were assessed for peritumoral edema and tumor border shape. RESULTS: The atypical and malignant meningiomas showed higher levels of tenascin expression than the typical meningiomas. The more sensitive messenger ribonucleic acid-based methods confirmed this finding. Tenascin expression was correlated with peritumoral edema and VEGF expression but not with tumor border shape. In the 13 tumors with marked tenascin expression, peritumoral edema was Grade 0 in one, Grade 1 in three, and Grade 2 in nine specimens. In the same 13 tumors, VEGF expression was Grade 1 in five and Grade 2 in eight specimens, and the findings for tumor border shape were Grade 0 in seven, Grade 1 in four, and Grade 2 in two specimens. CONCLUSION: In meningiomas, tenascin expression is correlated with anaplasia, tumor-associated edema, and VEGF expression but not with tumor border shape. This protein may play a role in the neoplastic and/or angiogenic processes in atypical and malignant meningiomas and may thus be a potential target for meningioma therapy.",
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T1 - Tenascin in meningioma

T2 - Expression is correlated with anaplasia, vascular endothelial growth factor expression, and peritumoral edema but not with tumor border shape

AU - Kiliç, Türker

AU - Bayri, Yaşar

AU - Özduman, Koray

AU - Acar, Melih

AU - Diren, Semin

AU - Kurtkaya, Özlem

AU - Ekinci, Gazanfer

AU - Buǧra, Kuyaş

AU - Sav, Aydin

AU - Memet Özek, M.

AU - Necmettin Pamir, M.

AU - Piepmeier, Joseph M.

AU - Lesniak, Maciej S.

AU - Brem, Henry

AU - Kaye, Andrew H.

AU - Rutka, James T.

PY - 2002/7/1

Y1 - 2002/7/1

N2 - OBJECTIVE: Tenascin is an extracellular matrix glycoprotein that is expressed during embryogenesis, inflammation, angiogenesis, and carcinogenesis. The aim of this study was to investigate how tenascin expression relates to histological grade, angiogenesis, and radiological findings in meningiomas. METHODS: Twenty typical, 20 atypical, and 5 malignant meningiomas were studied retrospectively. Tenascin expression and vascular endothelial growth factor (VEGF) expression in the tumor tissue were investigated by immunohistochemistry. Tenascin messenger ribonucleic acid expression was also studied by comparative reverse transcriptase-polymerase chain reaction. Magnetic resonance images from each case were assessed for peritumoral edema and tumor border shape. RESULTS: The atypical and malignant meningiomas showed higher levels of tenascin expression than the typical meningiomas. The more sensitive messenger ribonucleic acid-based methods confirmed this finding. Tenascin expression was correlated with peritumoral edema and VEGF expression but not with tumor border shape. In the 13 tumors with marked tenascin expression, peritumoral edema was Grade 0 in one, Grade 1 in three, and Grade 2 in nine specimens. In the same 13 tumors, VEGF expression was Grade 1 in five and Grade 2 in eight specimens, and the findings for tumor border shape were Grade 0 in seven, Grade 1 in four, and Grade 2 in two specimens. CONCLUSION: In meningiomas, tenascin expression is correlated with anaplasia, tumor-associated edema, and VEGF expression but not with tumor border shape. This protein may play a role in the neoplastic and/or angiogenic processes in atypical and malignant meningiomas and may thus be a potential target for meningioma therapy.

AB - OBJECTIVE: Tenascin is an extracellular matrix glycoprotein that is expressed during embryogenesis, inflammation, angiogenesis, and carcinogenesis. The aim of this study was to investigate how tenascin expression relates to histological grade, angiogenesis, and radiological findings in meningiomas. METHODS: Twenty typical, 20 atypical, and 5 malignant meningiomas were studied retrospectively. Tenascin expression and vascular endothelial growth factor (VEGF) expression in the tumor tissue were investigated by immunohistochemistry. Tenascin messenger ribonucleic acid expression was also studied by comparative reverse transcriptase-polymerase chain reaction. Magnetic resonance images from each case were assessed for peritumoral edema and tumor border shape. RESULTS: The atypical and malignant meningiomas showed higher levels of tenascin expression than the typical meningiomas. The more sensitive messenger ribonucleic acid-based methods confirmed this finding. Tenascin expression was correlated with peritumoral edema and VEGF expression but not with tumor border shape. In the 13 tumors with marked tenascin expression, peritumoral edema was Grade 0 in one, Grade 1 in three, and Grade 2 in nine specimens. In the same 13 tumors, VEGF expression was Grade 1 in five and Grade 2 in eight specimens, and the findings for tumor border shape were Grade 0 in seven, Grade 1 in four, and Grade 2 in two specimens. CONCLUSION: In meningiomas, tenascin expression is correlated with anaplasia, tumor-associated edema, and VEGF expression but not with tumor border shape. This protein may play a role in the neoplastic and/or angiogenic processes in atypical and malignant meningiomas and may thus be a potential target for meningioma therapy.

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KW - Extracellular matrix

KW - Meningioma

KW - Peritumoral edema

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