TY - JOUR
T1 - Ten-year survival and late sequelae in testicular cancer patients treated with cisplatin, vinblastine, and bleomycin
AU - Stoter, G.
AU - Koopman, A.
AU - Vendrik, C. P J
AU - Struyvenberg, A.
AU - Sleyfer Th., D.
AU - Willemse, P. H B
AU - Schraffordt Koops, H.
AU - Van Oosterom, A. T.
AU - Ten Bokkel Huinink, W. W.
AU - Pinedo, H. M.
PY - 1989
Y1 - 1989
N2 - This 10-year follow-up study of 91 patients with disseminated testicular nonseminomatous cancer, treated with cisplatin, vinblastine, and bleomycin (PVB) induction chemotherapy and vinblastine plus bleomycin maintenance chemotherapy for a planned period of 2 years, shows a 63% cure rate. The predominant long-term sequelae are neurological and sexual dysfunction in 68% and 40% of patients, respectively. Two patients died of myocardial infarction. Sixteen percent of patients developed hypertension, 23% Raynaud's phenomenon, and 25% ototoxicity. Despite the long-term side effects, 90% of the patients who responded to a questionnaire are fully employed. This study shows that the maintenance chemotherapy has contributed to the incidence and/or degree of neurotoxicity, hypertension, and renal function disturbance.
AB - This 10-year follow-up study of 91 patients with disseminated testicular nonseminomatous cancer, treated with cisplatin, vinblastine, and bleomycin (PVB) induction chemotherapy and vinblastine plus bleomycin maintenance chemotherapy for a planned period of 2 years, shows a 63% cure rate. The predominant long-term sequelae are neurological and sexual dysfunction in 68% and 40% of patients, respectively. Two patients died of myocardial infarction. Sixteen percent of patients developed hypertension, 23% Raynaud's phenomenon, and 25% ototoxicity. Despite the long-term side effects, 90% of the patients who responded to a questionnaire are fully employed. This study shows that the maintenance chemotherapy has contributed to the incidence and/or degree of neurotoxicity, hypertension, and renal function disturbance.
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M3 - Article
C2 - 2474060
AN - SCOPUS:0024369544
SN - 0732-183X
VL - 7
SP - 1099
EP - 1104
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 8
ER -