Ten things you should know about transposable elements

Guillaume Bourque, Kathleen Burns, Mary Gehring, Vera Gorbunova, Andrei Seluanov, Molly Hammell, Michaël Imbeault, Zsuzsanna Izsvák, Henry L. Levin, Todd S. Macfarlan, Dixie L. Mager, Cédric Feschotte

Research output: Contribution to journalReview article

Abstract

Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.

Original languageEnglish (US)
Number of pages1
JournalGenome biology
Volume19
Issue number1
DOIs
StatePublished - Nov 19 2018

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DNA Transposable Elements
transposons
genome
Genome Components
genomics
assay
Genomics
Genome
Biological Sciences
organisms
assays
organism

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Cite this

Bourque, G., Burns, K., Gehring, M., Gorbunova, V., Seluanov, A., Hammell, M., ... Feschotte, C. (2018). Ten things you should know about transposable elements. Genome biology, 19(1). https://doi.org/10.1186/s13059-018-1577-z

Ten things you should know about transposable elements. / Bourque, Guillaume; Burns, Kathleen; Gehring, Mary; Gorbunova, Vera; Seluanov, Andrei; Hammell, Molly; Imbeault, Michaël; Izsvák, Zsuzsanna; Levin, Henry L.; Macfarlan, Todd S.; Mager, Dixie L.; Feschotte, Cédric.

In: Genome biology, Vol. 19, No. 1, 19.11.2018.

Research output: Contribution to journalReview article

Bourque, G, Burns, K, Gehring, M, Gorbunova, V, Seluanov, A, Hammell, M, Imbeault, M, Izsvák, Z, Levin, HL, Macfarlan, TS, Mager, DL & Feschotte, C 2018, 'Ten things you should know about transposable elements', Genome biology, vol. 19, no. 1. https://doi.org/10.1186/s13059-018-1577-z
Bourque G, Burns K, Gehring M, Gorbunova V, Seluanov A, Hammell M et al. Ten things you should know about transposable elements. Genome biology. 2018 Nov 19;19(1). https://doi.org/10.1186/s13059-018-1577-z
Bourque, Guillaume ; Burns, Kathleen ; Gehring, Mary ; Gorbunova, Vera ; Seluanov, Andrei ; Hammell, Molly ; Imbeault, Michaël ; Izsvák, Zsuzsanna ; Levin, Henry L. ; Macfarlan, Todd S. ; Mager, Dixie L. ; Feschotte, Cédric. / Ten things you should know about transposable elements. In: Genome biology. 2018 ; Vol. 19, No. 1.
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