Ten putative contributors to the obesity epidemic

Emily J. McAllister, Nikhil V. Dhurandhar, Scott W. Keith, Louis J. Aronne, Jamie Barger, Monica Baskin, Ruth M. Benca, Joseph Biggio, Mary M. Boggiano, Joe C. Eisenmann, Mai Elobeid, Kevin R. Fontaine, Peter Gluckman, Erin C. Hanlon, Peter Katzmarzyk, Angelo Pietrobelli, David T. Redden, Douglas M. Ruden, Chenxi Wang, Robert A. WaterlandSuzanne M. Wright, David B. Allison

Research output: Contribution to journalArticle

Abstract

The obesity epidemic is a global issue and shows no signs of abating, while the cause of this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally-driven declines in physical activity are the alleged perpetrators for the epidemic, despite a lack of solid evidence to demonstrate their causal role. While both may contribute to obesity, we call attention to their unquestioned dominance in program funding and public efforts to reduce obesity, and propose several alternative putative contributors that would benefit from equal consideration and attention. Evidence for microorganisms, epigenetics, increasing maternal age, greater fecundity among people with higher adiposity, assortative mating, sleep debt, endocrine disruptors, pharmaceutical iatrogenesis, reduction in variability of ambient temperatures, and intrauterine and intergenerational effects as contributing factors to the obesity epidemic are reviewed herein. While the evidence is strong for some contributors such as pharmaceutical-induced weight gain, it is still emerging for other reviewed factors. Considering the role of such putative etiological factors of obesity may lead to comprehensive, cause specific, and effective strategies for prevention and treatment of this global epidemic.

Original languageEnglish (US)
Pages (from-to)868-913
Number of pages46
JournalCritical Reviews in Food Science and Nutrition
Volume49
Issue number10
DOIs
StatePublished - Nov 2009

Fingerprint

Drug products
obesity
Obesity
Microorganisms
Marketing
Endocrine Disruptors
drugs
debt
endocrine-disrupting chemicals
assortative mating
Maternal Age
Adiposity
adiposity
sleep
Epigenomics
epigenetics
funding
Pharmaceutical Preparations
physical activity
dominance (genetics)

Keywords

  • Genetics
  • Infections
  • Intrauterine
  • Obesity
  • Pharmaceutical

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering

Cite this

McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., ... Allison, D. B. (2009). Ten putative contributors to the obesity epidemic. Critical Reviews in Food Science and Nutrition, 49(10), 868-913. https://doi.org/10.1080/10408390903372599

Ten putative contributors to the obesity epidemic. / McAllister, Emily J.; Dhurandhar, Nikhil V.; Keith, Scott W.; Aronne, Louis J.; Barger, Jamie; Baskin, Monica; Benca, Ruth M.; Biggio, Joseph; Boggiano, Mary M.; Eisenmann, Joe C.; Elobeid, Mai; Fontaine, Kevin R.; Gluckman, Peter; Hanlon, Erin C.; Katzmarzyk, Peter; Pietrobelli, Angelo; Redden, David T.; Ruden, Douglas M.; Wang, Chenxi; Waterland, Robert A.; Wright, Suzanne M.; Allison, David B.

In: Critical Reviews in Food Science and Nutrition, Vol. 49, No. 10, 11.2009, p. 868-913.

Research output: Contribution to journalArticle

McAllister, EJ, Dhurandhar, NV, Keith, SW, Aronne, LJ, Barger, J, Baskin, M, Benca, RM, Biggio, J, Boggiano, MM, Eisenmann, JC, Elobeid, M, Fontaine, KR, Gluckman, P, Hanlon, EC, Katzmarzyk, P, Pietrobelli, A, Redden, DT, Ruden, DM, Wang, C, Waterland, RA, Wright, SM & Allison, DB 2009, 'Ten putative contributors to the obesity epidemic', Critical Reviews in Food Science and Nutrition, vol. 49, no. 10, pp. 868-913. https://doi.org/10.1080/10408390903372599
McAllister EJ, Dhurandhar NV, Keith SW, Aronne LJ, Barger J, Baskin M et al. Ten putative contributors to the obesity epidemic. Critical Reviews in Food Science and Nutrition. 2009 Nov;49(10):868-913. https://doi.org/10.1080/10408390903372599
McAllister, Emily J. ; Dhurandhar, Nikhil V. ; Keith, Scott W. ; Aronne, Louis J. ; Barger, Jamie ; Baskin, Monica ; Benca, Ruth M. ; Biggio, Joseph ; Boggiano, Mary M. ; Eisenmann, Joe C. ; Elobeid, Mai ; Fontaine, Kevin R. ; Gluckman, Peter ; Hanlon, Erin C. ; Katzmarzyk, Peter ; Pietrobelli, Angelo ; Redden, David T. ; Ruden, Douglas M. ; Wang, Chenxi ; Waterland, Robert A. ; Wright, Suzanne M. ; Allison, David B. / Ten putative contributors to the obesity epidemic. In: Critical Reviews in Food Science and Nutrition. 2009 ; Vol. 49, No. 10. pp. 868-913.
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