Abstract
The hippocampus, medial dorsal thalamus and the perirhinal and entorhinal cortices are essential for visual recognition memory whereas the neural substrates underlying olfactory recognition memories are less well characterized. In the present study we combined chemogenetic inactivation with a social odor recognition memory (SORM) task to test the hypothesis that the medial prefrontal cortex (mPFC) is involved in recognition memory. We demonstrate that temporary chemogenetic inactivation of the mPFC prior to an encoding session impairs social odor recognition memory, whereas silencing the mPFC just prior to the recognition session was without effect. Our data support the critical role of the mPFC in the formation rather than retrieval of social odor memory.
Original language | English (US) |
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Pages (from-to) | 115-121 |
Number of pages | 7 |
Journal | Neurobiology of Learning and Memory |
Volume | 161 |
DOIs | |
State | Published - May 2019 |
Keywords
- Chemogenetics
- Prefrontal cortex
- Recognition memory
- Social odor
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Cognitive Neuroscience
- Behavioral Neuroscience