Temporal trends in human immunodeficiency virus type 1 seroconversion 1984-1989

A report from the multicenter AIDS cohort study (macs)

Lawrence A. Kingsley, Susan Y J Zhou, Helena Bacellar, Charles R. Rinaldo, Joan Chmiel, Roger Detels, Alfred Saah, Mark Vanraden, Monto Ho, Alvaro Munoz

Research output: Contribution to journalArticle

Abstract

The 5-year temporal trends in human immunodeficiency virus type 1 (HIV-1) seroconversion between 1984 and 1989 among homosexual/bisexual men participating in the Multicenter AIDS Cohort Study (MACS) are reported. Of 3,262 initially seronegative men, 368 (11.3%) had seroconverted by December 31, 1989. Although the incidence of seroconversion declined precipitously during the first 3 years of follow-up (from 4.1% to 0.9% per 6 months), no evidence for a further substantial reduction was noted after mid-1987, since 6-month incidence rates ranged between 0.5% and 1.2%. The Chicago cohort experienced an increase in HIV-1 seroconversion during both semesters of 1989; 2.1% and 1.6% per 6 months, respectively, became newly infected. Other MACS centers did not report such an increase. Center-specific differences were observed by race; black men were at higher seroconversion risk than white men in Baltimore/Washington (relative risk (RR) = 3.4) and Chicago (RR = 2.4), while Hispanic men were at higher risk than white men in Chicago (RR = 3.3). Younger age (

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalAmerican Journal of Epidemiology
Volume134
Issue number4
StatePublished - Aug 15 1991

Fingerprint

HIV-1
Acquired Immunodeficiency Syndrome
Cohort Studies
Baltimore
Incidence
Hispanic Americans
Seroconversion
Sexual Minorities

Keywords

  • Acquired immunodeficiency syndrome
  • HIV
  • HIV seropositivity
  • HIV seroprevalence

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Temporal trends in human immunodeficiency virus type 1 seroconversion 1984-1989 : A report from the multicenter AIDS cohort study (macs). / Kingsley, Lawrence A.; Zhou, Susan Y J; Bacellar, Helena; Rinaldo, Charles R.; Chmiel, Joan; Detels, Roger; Saah, Alfred; Vanraden, Mark; Ho, Monto; Munoz, Alvaro.

In: American Journal of Epidemiology, Vol. 134, No. 4, 15.08.1991, p. 331-339.

Research output: Contribution to journalArticle

Kingsley, LA, Zhou, SYJ, Bacellar, H, Rinaldo, CR, Chmiel, J, Detels, R, Saah, A, Vanraden, M, Ho, M & Munoz, A 1991, 'Temporal trends in human immunodeficiency virus type 1 seroconversion 1984-1989: A report from the multicenter AIDS cohort study (macs)', American Journal of Epidemiology, vol. 134, no. 4, pp. 331-339.
Kingsley, Lawrence A. ; Zhou, Susan Y J ; Bacellar, Helena ; Rinaldo, Charles R. ; Chmiel, Joan ; Detels, Roger ; Saah, Alfred ; Vanraden, Mark ; Ho, Monto ; Munoz, Alvaro. / Temporal trends in human immunodeficiency virus type 1 seroconversion 1984-1989 : A report from the multicenter AIDS cohort study (macs). In: American Journal of Epidemiology. 1991 ; Vol. 134, No. 4. pp. 331-339.
@article{ef125772052f48078466a10de44768d7,
title = "Temporal trends in human immunodeficiency virus type 1 seroconversion 1984-1989: A report from the multicenter AIDS cohort study (macs)",
abstract = "The 5-year temporal trends in human immunodeficiency virus type 1 (HIV-1) seroconversion between 1984 and 1989 among homosexual/bisexual men participating in the Multicenter AIDS Cohort Study (MACS) are reported. Of 3,262 initially seronegative men, 368 (11.3{\%}) had seroconverted by December 31, 1989. Although the incidence of seroconversion declined precipitously during the first 3 years of follow-up (from 4.1{\%} to 0.9{\%} per 6 months), no evidence for a further substantial reduction was noted after mid-1987, since 6-month incidence rates ranged between 0.5{\%} and 1.2{\%}. The Chicago cohort experienced an increase in HIV-1 seroconversion during both semesters of 1989; 2.1{\%} and 1.6{\%} per 6 months, respectively, became newly infected. Other MACS centers did not report such an increase. Center-specific differences were observed by race; black men were at higher seroconversion risk than white men in Baltimore/Washington (relative risk (RR) = 3.4) and Chicago (RR = 2.4), while Hispanic men were at higher risk than white men in Chicago (RR = 3.3). Younger age (",
keywords = "Acquired immunodeficiency syndrome, HIV, HIV seropositivity, HIV seroprevalence",
author = "Kingsley, {Lawrence A.} and Zhou, {Susan Y J} and Helena Bacellar and Rinaldo, {Charles R.} and Joan Chmiel and Roger Detels and Alfred Saah and Mark Vanraden and Monto Ho and Alvaro Munoz",
year = "1991",
month = "8",
day = "15",
language = "English (US)",
volume = "134",
pages = "331--339",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Temporal trends in human immunodeficiency virus type 1 seroconversion 1984-1989

T2 - A report from the multicenter AIDS cohort study (macs)

AU - Kingsley, Lawrence A.

AU - Zhou, Susan Y J

AU - Bacellar, Helena

AU - Rinaldo, Charles R.

AU - Chmiel, Joan

AU - Detels, Roger

AU - Saah, Alfred

AU - Vanraden, Mark

AU - Ho, Monto

AU - Munoz, Alvaro

PY - 1991/8/15

Y1 - 1991/8/15

N2 - The 5-year temporal trends in human immunodeficiency virus type 1 (HIV-1) seroconversion between 1984 and 1989 among homosexual/bisexual men participating in the Multicenter AIDS Cohort Study (MACS) are reported. Of 3,262 initially seronegative men, 368 (11.3%) had seroconverted by December 31, 1989. Although the incidence of seroconversion declined precipitously during the first 3 years of follow-up (from 4.1% to 0.9% per 6 months), no evidence for a further substantial reduction was noted after mid-1987, since 6-month incidence rates ranged between 0.5% and 1.2%. The Chicago cohort experienced an increase in HIV-1 seroconversion during both semesters of 1989; 2.1% and 1.6% per 6 months, respectively, became newly infected. Other MACS centers did not report such an increase. Center-specific differences were observed by race; black men were at higher seroconversion risk than white men in Baltimore/Washington (relative risk (RR) = 3.4) and Chicago (RR = 2.4), while Hispanic men were at higher risk than white men in Chicago (RR = 3.3). Younger age (

AB - The 5-year temporal trends in human immunodeficiency virus type 1 (HIV-1) seroconversion between 1984 and 1989 among homosexual/bisexual men participating in the Multicenter AIDS Cohort Study (MACS) are reported. Of 3,262 initially seronegative men, 368 (11.3%) had seroconverted by December 31, 1989. Although the incidence of seroconversion declined precipitously during the first 3 years of follow-up (from 4.1% to 0.9% per 6 months), no evidence for a further substantial reduction was noted after mid-1987, since 6-month incidence rates ranged between 0.5% and 1.2%. The Chicago cohort experienced an increase in HIV-1 seroconversion during both semesters of 1989; 2.1% and 1.6% per 6 months, respectively, became newly infected. Other MACS centers did not report such an increase. Center-specific differences were observed by race; black men were at higher seroconversion risk than white men in Baltimore/Washington (relative risk (RR) = 3.4) and Chicago (RR = 2.4), while Hispanic men were at higher risk than white men in Chicago (RR = 3.3). Younger age (

KW - Acquired immunodeficiency syndrome

KW - HIV

KW - HIV seropositivity

KW - HIV seroprevalence

UR - http://www.scopus.com/inward/record.url?scp=0026009084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026009084&partnerID=8YFLogxK

M3 - Article

VL - 134

SP - 331

EP - 339

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 4

ER -