Temporal trends in gonococcal antibiotic resistance in baltimore

Cindy A. Reichart, Theresa Neumann, Phyllis Foreman, Jonathan Mark Zenilman, Edward W. Hook

Research output: Contribution to journalArticle

Abstract

Each month from August 1986 through July 1990, clinical and laboratory data were evaluated for the first 25 urethral isolates of Neisseria gonorrhoeae from men attending a Baltimore sexually transmitted disease (STD) clinic as part of an effort to understand factors that contribute to changes in gonococcal antimicrobial susceptibility. During the 48-month study period, 1193 gonococcal isolates were evaluated; the proportion of penicillinase-producing N. gonorrhoeae (PPNG) isolates steadily increased, the prevalence of tetracycline-resistant N. gonorrhoeae (TRNG) remained relatively stable, and chromosomally mediated penicillin resistance increased steadily during the first 5 6-month intervals, then decreased, only to increase again during the final 2 6-month intervals. Changes in antibiotic treatment regimens for gonorrhea were associated with changes in the prevalence of chromosomally mediated penicillin resistance. In a supplementary study to characterize patterns of antibiotic use among men and women attending the STD clinics, 9% of patients reported antibiotic use in the 2 weeks prior to clinic visit. Antibiotics were taken prior to clinic attendance by 65% of patients reporting antibiotic use, because of concerns regarding possible STD or STD exposure. These patients were significantly less likely to be culture positive for N. gonorrhoeae when compared with patients who did not report antibiotic use. Temporal trends in N. gonorrhoeae antibiotic resistance appear to be influenced by many factors, including treatment regimens and self medication.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalSexually Transmitted Diseases
Volume19
Issue number4
StatePublished - 1992

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Baltimore
Microbial Drug Resistance
Neisseria gonorrhoeae
Sexually Transmitted Diseases
Anti-Bacterial Agents
Penicillin Resistance
Penicillinase
Self Medication
Gonorrhea
Ambulatory Care
Tetracycline
Therapeutics

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases
  • Microbiology (medical)
  • Public Health, Environmental and Occupational Health

Cite this

Reichart, C. A., Neumann, T., Foreman, P., Zenilman, J. M., & Hook, E. W. (1992). Temporal trends in gonococcal antibiotic resistance in baltimore. Sexually Transmitted Diseases, 19(4), 213-218.

Temporal trends in gonococcal antibiotic resistance in baltimore. / Reichart, Cindy A.; Neumann, Theresa; Foreman, Phyllis; Zenilman, Jonathan Mark; Hook, Edward W.

In: Sexually Transmitted Diseases, Vol. 19, No. 4, 1992, p. 213-218.

Research output: Contribution to journalArticle

Reichart, CA, Neumann, T, Foreman, P, Zenilman, JM & Hook, EW 1992, 'Temporal trends in gonococcal antibiotic resistance in baltimore', Sexually Transmitted Diseases, vol. 19, no. 4, pp. 213-218.
Reichart, Cindy A. ; Neumann, Theresa ; Foreman, Phyllis ; Zenilman, Jonathan Mark ; Hook, Edward W. / Temporal trends in gonococcal antibiotic resistance in baltimore. In: Sexually Transmitted Diseases. 1992 ; Vol. 19, No. 4. pp. 213-218.
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