Temporal organization of atrial activity and irregular ventricular rhythm during spontaneous atrial fibrillation: An in vivo study in the horse

Anna R.M. Gelzer, N. Sydney Moïse, Dhananjay Vaidya, Karin A. Wagner, José Jalife

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Atrial fibrillation (AF) is common in healthy horses. We studied the temporal organization of AF to test the hypothesis that the arrhythmia is governed by a high degree of periodicity and therefore is not random in the horse. Further, we surmised that concealed conduction of AF impulses in the AV node results in an inverse relationship between AF frequency and ventricular frequency. Methods and Results: Fast Fourier transform (FFT) analysis of atrial activity was done on signal-averaged ECGs (n = 11) and atrial electrograms (n = 3) of horses with AF at control (C), after quinidine sulfate (22 mg/kg by mouth every 2 hours) at 50% time to conversion (T50), and immediately before conversion (T90) to sinus rhythm. FFT always revealed a single dominant frequency peak. The mean dominant frequency decreased until conversion (C = 6.84 ± 0.85 Hz, T50 = 4.87 ± 1.5 Hz, T90 = 3.41 ± 1.18 Hz; P < 0.001). Mean AA intervals (n = 500) gradually increased after quinidine. Mean RR intervals (n = 500), standard deviation of the mean (SDM), Poincare plots, and serial autocorrelograms (SACs) of 500 RR intervals were measured at C and T90 to determine the ventricular response to AF and quinidine-induced changes in the variability of the ventricular response. Mean RR interval and SDM were reduced after quinidine (C = 1431 ± 266 msec and 695 ± 23 msec; T90 = 974 ± 116 msec and 273 ± 158 msec, respectively; P < 0.01). Poincare plots and SAC at C and at T90 revealed a significant correlation of consecutive RR intervals typical of a system with a deterministic behavior. At T90, the variability of RR intervals was reduced and the overall periodicity of RR intervals was increased after quinidine administration. Conclusion: In the horse, AF is a complex arrhythmia characterized by a high degree of underlying periodicity. The inverse AA-to- RR interval relationship and reduced variability of RR intervals after quinidine suggest that the ventricular response during AF results from rate- dependent concealment of AF wavelets bombarding the AV node, which nevertheless results in a significant degree of short-term predictability of beat-to-beat changes in RR intervals.

Original languageEnglish (US)
Pages (from-to)773-784
Number of pages12
JournalJournal of cardiovascular electrophysiology
Volume11
Issue number7
DOIs
StatePublished - 2000

Keywords

  • Atrial fibrillation
  • Horse
  • Periodicity
  • Spectral analysis
  • Ventricular response

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'Temporal organization of atrial activity and irregular ventricular rhythm during spontaneous atrial fibrillation: An in vivo study in the horse'. Together they form a unique fingerprint.

Cite this