Temporal lobe pathology in schizophrenia: A quantitative magnetic resonance imaging study

R. L. Suddath, M. F. Casanova, T. E. Goldberg, D. G. Daniel, J. R. Kelsoe, Daniel Weinberger

Research output: Contribution to journalArticle

Abstract

Although numerous studies have confirmed the presence of larger cerebral ventricles in schizophrenia, the locus of tissue loss remains elusive. By analyzing magnetic resonance scans with computerized image analysis, the authors determined gray and white matter volumes in the temporal lobes and prefrontal regions of 17 patients with schizophrenia and 17 age- and sex-matched normal subjects. The volume of temporal lobe gray matter was 20% smaller in the patients than in the control subjects. The lateral ventricular volume was 67% larger in the patients and, when normalized for brain size, correlated inversely with the volume of temporal lobe gray matter.

Original languageEnglish (US)
Pages (from-to)464-472
Number of pages9
JournalAmerican Journal of Psychiatry
Volume146
Issue number4
StatePublished - 1989
Externally publishedYes

Fingerprint

Temporal Lobe
Schizophrenia
Magnetic Resonance Imaging
Pathology
Cerebral Ventricles
Magnetic Resonance Spectroscopy
Brain
Gray Matter

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Suddath, R. L., Casanova, M. F., Goldberg, T. E., Daniel, D. G., Kelsoe, J. R., & Weinberger, D. (1989). Temporal lobe pathology in schizophrenia: A quantitative magnetic resonance imaging study. American Journal of Psychiatry, 146(4), 464-472.

Temporal lobe pathology in schizophrenia : A quantitative magnetic resonance imaging study. / Suddath, R. L.; Casanova, M. F.; Goldberg, T. E.; Daniel, D. G.; Kelsoe, J. R.; Weinberger, Daniel.

In: American Journal of Psychiatry, Vol. 146, No. 4, 1989, p. 464-472.

Research output: Contribution to journalArticle

Suddath, RL, Casanova, MF, Goldberg, TE, Daniel, DG, Kelsoe, JR & Weinberger, D 1989, 'Temporal lobe pathology in schizophrenia: A quantitative magnetic resonance imaging study', American Journal of Psychiatry, vol. 146, no. 4, pp. 464-472.
Suddath, R. L. ; Casanova, M. F. ; Goldberg, T. E. ; Daniel, D. G. ; Kelsoe, J. R. ; Weinberger, Daniel. / Temporal lobe pathology in schizophrenia : A quantitative magnetic resonance imaging study. In: American Journal of Psychiatry. 1989 ; Vol. 146, No. 4. pp. 464-472.
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