Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia

Ashley D. Harris, Victoria H. Roberton, Danielle L. Huckle, Neeraj Saxena, C. John Evans, Kevin Murphy, Judith E. Hall, Damian M. Bailey, Georgios Mitsis, Richard A.E. Edden, Richard G. Wise

Research output: Contribution to journalArticle

Abstract

Purpose: To demonstrate the feasibility of measuring the temporal dynamics of cerebral lactate concentration and examine these dynamics in human subjects using magnetic resonance spectroscopy (MRS) during hypoxia. Materials and Methods: A respiratory protocol consisting of 10-minute baseline normoxia, 20-minute inspiratory hypoxia, and ending with 10-minute normoxic recovery was used, throughout which lactate-edited MRS was performed. This was repeated four times in three subjects. A separate session was performed to measure blood lactate. Impulse response functions using end-tidal oxygen and blood lactate as system inputs and cerebral lactate as the system output were examined to describe the dynamics of the cerebral lactate response to a hypoxic challenge. Results: The average lactate increase was 20% ± 15% during the last half of the hypoxic challenge. Significant changes in cerebral lactate concentration were observed after 400 seconds. The average relative increase in blood lactate was 188% ± 95%. The temporal dynamics of cerebral lactate concentration was reproducibly demonstrated with 200-second time bins of MRS data (coefficient of variation 0.063 ± 0.035 between time bins in normoxia). The across-subject coefficient of variation was 0.333. Conclusion: The methods for measuring the dynamics of the cerebral lactate response developed here would be useful to further investigate the brain's response to hypoxia.

Original languageEnglish (US)
Pages (from-to)739-745
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume37
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • cerebral lactate
  • hypoxia
  • impulse response function
  • lactate
  • magnetic resonance spectroscopy
  • neuroimaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Harris, A. D., Roberton, V. H., Huckle, D. L., Saxena, N., Evans, C. J., Murphy, K., Hall, J. E., Bailey, D. M., Mitsis, G., Edden, R. A. E., & Wise, R. G. (2013). Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia. Journal of Magnetic Resonance Imaging, 37(3), 739-745. https://doi.org/10.1002/jmri.23815