Temporal and spatial regulation of chemotaxis

Miho Iijima, Yi Elaine Huang, Peter Devreotes

Research output: Contribution to journalReview articlepeer-review

252 Scopus citations


The ability to sense and respond to shallow gradients of extracellular signals is remarkably similar in Dictyostelium discoideum amoeba and mammalian leukoytes. Chemoattractant receptors and G proteins are fairly evenly distributed along the cell surface. Receptor occupancy generates local excitatory and global inhibitory processes that balance to control the chemotactic response. Uniform stimuli transiently recruit PI3Ks to, and release PTEN from, the plasma membrane, while gradients of chemoattractant cause the two enzymes to bind to the membrane at the front and back of the cell, respectively. Interference with PI3Ks alters chemotaxis, and disruption of PTEN broadens PI localization and actin polymerization in parallel. Thus, counteracting signals from the upstream elements of the pathway converge to regulate the key enzymes of PI metabolism, localize these lipids, and direct pseudopod formation.

Original languageEnglish (US)
Pages (from-to)469-478
Number of pages10
JournalDevelopmental Cell
Issue number4
StatePublished - Oct 1 2002

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


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