Telomeres, telomerase and senescence

Research output: Contribution to journalArticle

Abstract

Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de novo by telomerase, an unusual DNA polymerase. Telomerase is an RNP in which an essential RNA component provides the template for the added telomere repeats. Telomere length maintenance plays an essential role in cell viability.

Original languageEnglish (US)
Pages (from-to)363-369
Number of pages7
JournalBioEssays
Volume12
Issue number8
StatePublished - 1990
Externally publishedYes

Fingerprint

telomerase
Telomerase
telomeres
Telomere
Chromosomes
chromosomes
Telomere Homeostasis
Tandem Repeat Sequences
DNA-Directed DNA Polymerase
tandem repeat sequences
Cell Survival
DNA-directed DNA polymerase
Cells
RNA
cell viability

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Telomeres, telomerase and senescence. / Greider, Carol W.

In: BioEssays, Vol. 12, No. 8, 1990, p. 363-369.

Research output: Contribution to journalArticle

Greider, CW 1990, 'Telomeres, telomerase and senescence', BioEssays, vol. 12, no. 8, pp. 363-369.
Greider, Carol W. / Telomeres, telomerase and senescence. In: BioEssays. 1990 ; Vol. 12, No. 8. pp. 363-369.
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