Telomeres, telomerase and senescence

Research output: Contribution to journalReview articlepeer-review

216 Scopus citations


Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de novo by telomerase, an unusual DNA polymerase. Telomerase is an RNP in which an essential RNA component provides the template for the added telomere repeats. Telomere length maintenance plays an essential role in cell viability.

Original languageEnglish (US)
Pages (from-to)363-369
Number of pages7
Issue number8
StatePublished - Aug 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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