TY - JOUR
T1 - Telomeres and age-related disease
T2 - How telomere biology informs clinical paradigms
AU - Armanios, Mary
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis. These disorders have recognizable clinical manifestations, and the telomere defect explains their genetics and informs the approach to their treatment. Here, I review how telomere biology has become intimately connected to clinical paradigms both for understanding pathophysiology and for individualizing therapy decisions. I also critically examine nuances of interpreting telomere length measurement in clinical studies.
AB - Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis. These disorders have recognizable clinical manifestations, and the telomere defect explains their genetics and informs the approach to their treatment. Here, I review how telomere biology has become intimately connected to clinical paradigms both for understanding pathophysiology and for individualizing therapy decisions. I also critically examine nuances of interpreting telomere length measurement in clinical studies.
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U2 - 10.1172/JCI66370
DO - 10.1172/JCI66370
M3 - Review article
C2 - 23454763
AN - SCOPUS:84874611617
SN - 0021-9738
VL - 123
SP - 996
EP - 1002
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 3
ER -