Telomere-related sequences at interstitial sites in the human genome

Richard A. Wells, Gregory G. Germino, Sanjeev Krishna, Veronica J. Buckle, Stephen T. Reeders

Research output: Contribution to journalArticle

Abstract

The ends (telomeres) of eukaryotic chromosomes are protected from degradation and from loss during DNA replication by buffers of simple tandem repetitive sequence. The nucleotide sequence of these telomeric arrays is fundamental to telomere function as a site for protein and ribonucleo-protein binding and varies only slightly in a wide range of organisms. We present evidence that arrays of this human telomeric sequence, TTAGGG, are present not only at the ends of human chromosomes but also at numerous interstitial sites. These interstitial loci share nucleotide sequence similarity outside the repetitive array, suggesting that they are related functionally or have evolved from a common progenitor locus.

Original languageEnglish (US)
Pages (from-to)699-704
Number of pages6
JournalGenomics
Volume8
Issue number4
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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  • Cite this

    Wells, R. A., Germino, G. G., Krishna, S., Buckle, V. J., & Reeders, S. T. (1990). Telomere-related sequences at interstitial sites in the human genome. Genomics, 8(4), 699-704. https://doi.org/10.1016/0888-7543(90)90257-U