Telomere length and risk of Parkinson's disease

Hao Wang, Honglei Chen, Xiang Gao, Monica McGrath, Dwayne Deer, Immaculata De Vivo, Michael A. Schwarzschild, Alberto Ascherio

Research output: Contribution to journalArticle

Abstract

We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.

Original languageEnglish (US)
Pages (from-to)302-305
Number of pages4
JournalMovement Disorders
Volume23
Issue number2
DOIs
StatePublished - Jan 30 2008
Externally publishedYes

Keywords

  • Nested case-control study
  • Parkinson's disease
  • Relative risk
  • Telomere length

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Wang, H., Chen, H., Gao, X., McGrath, M., Deer, D., De Vivo, I., Schwarzschild, M. A., & Ascherio, A. (2008). Telomere length and risk of Parkinson's disease. Movement Disorders, 23(2), 302-305. https://doi.org/10.1002/mds.21867