Telomere length and cognitive function in community-dwelling elders: Findings from the Health ABC Study

Kristine Yaffe, Karla Lindquist, Molly Kluse, Richard Cawthon, Tamara Harris, Wen Chi Hsueh, Eleanor Marie Simonsick, Lewis Kuller, Rongling Li, Hilsa N. Ayonayon, Susan M. Rubin, Steven R. Cummings

Research output: Contribution to journalArticle

Abstract

Telomere shortening is a marker of cellular aging and has been associated with risk of Alzheimer's disease. Few studies have determined if telomere length is associated with cognitive decline in non-demented elders. We prospectively studied 2734 non-demented elders (mean age: 74 years). We measured cognition with the Modified Mini-Mental State Exam (3MS) and Digit Symbol Substitution Test (DSST) repeatedly over 7 years. Baseline telomere length was measured in blood leukocytes and classified by tertile as "short", "medium", or "long". At baseline, longer telomere length was associated with better DSST score (36.4, 34.9 and 34.4 points for long, medium and short, p

Original languageEnglish (US)
Pages (from-to)2055-2060
Number of pages6
JournalNeurobiology of Aging
Volume32
Issue number11
DOIs
StatePublished - Nov 2011
Externally publishedYes

Fingerprint

Independent Living
Telomere
Cognition
Health
Telomere Shortening
Cell Aging
Alzheimer Disease
Leukocytes

Keywords

  • Biomarker
  • Cognitive decline
  • Epidemiology
  • Genetics
  • Telomeres

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Yaffe, K., Lindquist, K., Kluse, M., Cawthon, R., Harris, T., Hsueh, W. C., ... Cummings, S. R. (2011). Telomere length and cognitive function in community-dwelling elders: Findings from the Health ABC Study. Neurobiology of Aging, 32(11), 2055-2060. https://doi.org/10.1016/j.neurobiolaging.2009.12.006

Telomere length and cognitive function in community-dwelling elders : Findings from the Health ABC Study. / Yaffe, Kristine; Lindquist, Karla; Kluse, Molly; Cawthon, Richard; Harris, Tamara; Hsueh, Wen Chi; Simonsick, Eleanor Marie; Kuller, Lewis; Li, Rongling; Ayonayon, Hilsa N.; Rubin, Susan M.; Cummings, Steven R.

In: Neurobiology of Aging, Vol. 32, No. 11, 11.2011, p. 2055-2060.

Research output: Contribution to journalArticle

Yaffe, K, Lindquist, K, Kluse, M, Cawthon, R, Harris, T, Hsueh, WC, Simonsick, EM, Kuller, L, Li, R, Ayonayon, HN, Rubin, SM & Cummings, SR 2011, 'Telomere length and cognitive function in community-dwelling elders: Findings from the Health ABC Study', Neurobiology of Aging, vol. 32, no. 11, pp. 2055-2060. https://doi.org/10.1016/j.neurobiolaging.2009.12.006
Yaffe, Kristine ; Lindquist, Karla ; Kluse, Molly ; Cawthon, Richard ; Harris, Tamara ; Hsueh, Wen Chi ; Simonsick, Eleanor Marie ; Kuller, Lewis ; Li, Rongling ; Ayonayon, Hilsa N. ; Rubin, Susan M. ; Cummings, Steven R. / Telomere length and cognitive function in community-dwelling elders : Findings from the Health ABC Study. In: Neurobiology of Aging. 2011 ; Vol. 32, No. 11. pp. 2055-2060.
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