Telomere content correlates with stage and prognosis in breast cancer

Colleen A. Fordyce, Christopher M Heaphy, Marco Bisoffi, Jessica L. Wyaco, Nancy E. Joste, Aroop Mangalik, Kathy B. Baumgartner, Richard N. Baumgartner, William C. Hunt, Jeffrey K. Griffith

Research output: Contribution to journalArticle

Abstract

Purpose. To evaluate the hypothesis that telomere DNA content (TC) in breast tumor tissue correlates with TNM staging and prognosis. Experimental design. Slot blot assay was used to quantitate TC in 70 disease-free normal tissues from multiple organ sites, and two independent sets of breast tumors containing a total of 140 samples. Non-parametric Rank-Sums tests, logistic regression and Cox proportional hazards models were used to evaluate the relationships between TC and tumor size, nodal involvement, TNM stage, 5-year survival and disease-free interval. Results. TC in 95% of normal tissues was 75-143% of that in the placental DNA standard, whereas only 50% of tumors had TC values in this range. TC was associated with tumor size (p=0.02), nodal involvement (p123% of standard), low TC (

Original languageEnglish (US)
Pages (from-to)193-202
Number of pages10
JournalBreast Cancer Research and Treatment
Volume99
Issue number2
DOIs
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

Telomere
Breast Neoplasms
DNA
Neoplasms
Neoplasm Staging
Nonparametric Statistics
Proportional Hazards Models
Disease-Free Survival
Research Design
Logistic Models

Keywords

  • Breast cancer
  • Genomic instability
  • Metastasis
  • Prognosis
  • Telomere
  • TNM staging

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Fordyce, C. A., Heaphy, C. M., Bisoffi, M., Wyaco, J. L., Joste, N. E., Mangalik, A., ... Griffith, J. K. (2006). Telomere content correlates with stage and prognosis in breast cancer. Breast Cancer Research and Treatment, 99(2), 193-202. https://doi.org/10.1007/s10549-006-9204-1

Telomere content correlates with stage and prognosis in breast cancer. / Fordyce, Colleen A.; Heaphy, Christopher M; Bisoffi, Marco; Wyaco, Jessica L.; Joste, Nancy E.; Mangalik, Aroop; Baumgartner, Kathy B.; Baumgartner, Richard N.; Hunt, William C.; Griffith, Jeffrey K.

In: Breast Cancer Research and Treatment, Vol. 99, No. 2, 09.2006, p. 193-202.

Research output: Contribution to journalArticle

Fordyce, CA, Heaphy, CM, Bisoffi, M, Wyaco, JL, Joste, NE, Mangalik, A, Baumgartner, KB, Baumgartner, RN, Hunt, WC & Griffith, JK 2006, 'Telomere content correlates with stage and prognosis in breast cancer', Breast Cancer Research and Treatment, vol. 99, no. 2, pp. 193-202. https://doi.org/10.1007/s10549-006-9204-1
Fordyce, Colleen A. ; Heaphy, Christopher M ; Bisoffi, Marco ; Wyaco, Jessica L. ; Joste, Nancy E. ; Mangalik, Aroop ; Baumgartner, Kathy B. ; Baumgartner, Richard N. ; Hunt, William C. ; Griffith, Jeffrey K. / Telomere content correlates with stage and prognosis in breast cancer. In: Breast Cancer Research and Treatment. 2006 ; Vol. 99, No. 2. pp. 193-202.
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