Telomerase RNA structure and function: Implications for dyskeratosis congenita

Jiunn Liang Chen; Carol W. Greider

doi:10.1016/j.tibs.2004.02.003

Telomerase RNA structure and function: Implications for dyskeratosis congenita

Jiunn Liang Chen, Carol W. Greider

School of Medicine

Research output: Contribution to journal › Review article › peer-review

122 Scopus citations

Abstract

Telomerase RNA is an intrinsic component of the telomerase enzyme. A short template sequence in the telomerase RNA is copied by the catalytic telomerase reverse transcriptase (TERT) to synthesize telomere repeats to chromosome ends. In addition to the template, other conserved RNA structural elements play important parts in catalysis as well as localization, maturation and assembly of telomerase. Telomerase RNA is mutated in the autosomal dominant form of the disease dyskeratosis congenita. Recent studies of telomerase RNA function and telomerase biogenesis have provided a basis for understanding the role of telomerase in this disease.

Original language	English (US)
Pages (from-to)	183-192
Number of pages	10
Journal	Trends in biochemical sciences
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.tibs.2004.02.003
State	Published - Apr 2004

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2004.02.003

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title = "Telomerase RNA structure and function: Implications for dyskeratosis congenita",

abstract = "Telomerase RNA is an intrinsic component of the telomerase enzyme. A short template sequence in the telomerase RNA is copied by the catalytic telomerase reverse transcriptase (TERT) to synthesize telomere repeats to chromosome ends. In addition to the template, other conserved RNA structural elements play important parts in catalysis as well as localization, maturation and assembly of telomerase. Telomerase RNA is mutated in the autosomal dominant form of the disease dyskeratosis congenita. Recent studies of telomerase RNA function and telomerase biogenesis have provided a basis for understanding the role of telomerase in this disease.",

author = "Chen, {Jiunn Liang} and Greider, {Carol W.}",

note = "Funding Information: We thank Nathaniel Comfort, Mary Armanios, Joe Gall and Rachel Green for critical reading of the article. We thank members of the Greider laboratory for helpful discussions. J.L.C. was supported by a postdoctoral fellowship from the Leukemia and Lymphoma Society. This work was supported by an NIH grant (AG09838) to C.W.G. and a MCEP pilot grant from the Institute for Cell Engineering at Johns Hopkins University.",

year = "2004",

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doi = "10.1016/j.tibs.2004.02.003",

language = "English (US)",

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pages = "183--192",

journal = "Trends in biochemical sciences",

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T2 - Implications for dyskeratosis congenita

AU - Chen, Jiunn Liang

AU - Greider, Carol W.

N1 - Funding Information: We thank Nathaniel Comfort, Mary Armanios, Joe Gall and Rachel Green for critical reading of the article. We thank members of the Greider laboratory for helpful discussions. J.L.C. was supported by a postdoctoral fellowship from the Leukemia and Lymphoma Society. This work was supported by an NIH grant (AG09838) to C.W.G. and a MCEP pilot grant from the Institute for Cell Engineering at Johns Hopkins University.

PY - 2004/4

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N2 - Telomerase RNA is an intrinsic component of the telomerase enzyme. A short template sequence in the telomerase RNA is copied by the catalytic telomerase reverse transcriptase (TERT) to synthesize telomere repeats to chromosome ends. In addition to the template, other conserved RNA structural elements play important parts in catalysis as well as localization, maturation and assembly of telomerase. Telomerase RNA is mutated in the autosomal dominant form of the disease dyskeratosis congenita. Recent studies of telomerase RNA function and telomerase biogenesis have provided a basis for understanding the role of telomerase in this disease.

AB - Telomerase RNA is an intrinsic component of the telomerase enzyme. A short template sequence in the telomerase RNA is copied by the catalytic telomerase reverse transcriptase (TERT) to synthesize telomere repeats to chromosome ends. In addition to the template, other conserved RNA structural elements play important parts in catalysis as well as localization, maturation and assembly of telomerase. Telomerase RNA is mutated in the autosomal dominant form of the disease dyskeratosis congenita. Recent studies of telomerase RNA function and telomerase biogenesis have provided a basis for understanding the role of telomerase in this disease.

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JO - Trends in biochemical sciences

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ER -

Telomerase RNA structure and function: Implications for dyskeratosis congenita

Abstract

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