Telomerase Reverse Transcriptase and p53 regulate mammalian peripheral nervous system and cns axon regeneration downstream of c-Myc

Jin Jin Ma, Xin Ju, Ren Jie Xu, Wei Hua Wang, Zong Ping Luo, Chang Mei Liu, Lei Yang, Bin Li, Jian Quan Chen, Bin Meng, Hui Lin Yang, Feng Quan Zhou, S. Saijilafu

Research output: Contribution to journalArticlepeer-review

Abstract

Although several genes have been identified to promote axon regeneration in the CNS, our understanding of the molecular mechanisms by which mammalian axon regeneration is regulated is still limited and fragmented. Here by using female mouse sensory axon and optic nerve regeneration as model systems, we reveal an unexpected role of telomerase reverse transcriptase (TERT) in regulation of axon regeneration. We also provide evidence that TERT and p53 act downstream of c-Myc to control sensory axon regeneration. More importantly, overexpression of p53 in sensory neurons and retinal ganglion cells is sufficient to promote sensory axon and optic never regeneration, respectively. The study reveals a novel c-Myc-TERT-p53 signaling pathway, expanding horizons for novel approaches promoting CNS axon regeneration.

Original languageEnglish (US)
Pages (from-to)9107-9118
Number of pages12
JournalJournal of Neuroscience
Volume39
Issue number46
DOIs
StatePublished - Nov 13 2019

Keywords

  • Axon Regeneration
  • C-Myc
  • Optic Nerve Regeneration
  • P53
  • Telomerase Reverse Transcriptase

ASJC Scopus subject areas

  • Neuroscience(all)

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