Telomerase protects developing neurons against DNA damage-induced cell death

Chengbiao Lu, Weiming Fu, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

In mitotic cells, telomerase adds repeats of a DNA sequence (TTAGGG) to the ends of chromosomes (telomeres) thereby maintaining their length and preventing cellular senescence. We recently reported that the catalytic subunit of telomerase (TERT) is expressed in neuronal progenitor cells and in early postmitotic neurons in the developing rodent brain. We now report that TERT can protect cultured PC12 cells and embryonic hippocampal neurons against death induced by DNA damage. Overexpression of TERT in PC12 cells increases their resistance to the topoisomerase inhibitors camptothecin and etoposide. Hippocampal neurons in which TERT levels are decreased using antisense technology exhibit increased vulnerability to the DNA-damaging agents. Emerging findings suggest that DNA damage may trigger the death of neurons during brain development and in neurodegenerative disorders. Our data therefore suggest roles for TERT in modulating such cell deaths.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalDevelopmental Brain Research
Volume131
Issue number1-2
DOIs
Publication statusPublished - Nov 26 2001

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Keywords

  • Apoptosis
  • Camptothecin
  • Cancer
  • Etoposide
  • Hippocampus
  • p53
  • TERT
  • Topoisomerase

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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