Telomerase and cancer: Revisiting the telomere hypothesis

Chantal Autexier; Carol W. Greider

doi:10.1016/0968-0004(96)10042-6

Telomerase and cancer: Revisiting the telomere hypothesis

Chantal Autexier, Carol W. Greider

Research output: Contribution to journal › Review article › peer-review

166 Scopus citations

Abstract

Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation.

Original language	English (US)
Pages (from-to)	387-391
Number of pages	5
Journal	Trends in biochemical sciences
Volume	21
Issue number	10
DOIs	https://doi.org/10.1016/0968-0004(96)10042-6
State	Published - Oct 1996
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/0968-0004(96)10042-6

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title = "Telomerase and cancer: Revisiting the telomere hypothesis",

abstract = "Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation.",

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AU - Autexier, Chantal

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AB - Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation.

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DO - 10.1016/0968-0004(96)10042-6

M3 - Review article

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Telomerase and cancer: Revisiting the telomere hypothesis

Abstract

ASJC Scopus subject areas

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