Telomerase and cancer: Revisiting the telomere hypothesis

Chantal Autexier, Carol W. Greider

Research output: Contribution to journalReview articlepeer-review

Abstract

Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalTrends in biochemical sciences
Volume21
Issue number10
DOIs
StatePublished - Oct 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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