Telomerase and cancer

Jerry W. Shay; Ying Zou; Eiso Hiyama; Woodring E. Wright

doi:10.1093/hmg/10.7.677

Telomerase and cancer

Jerry W. Shay, Ying Zou, Eiso Hiyama, Woodring E. Wright

Research output: Contribution to journal › Review article › peer-review

331 Scopus citations

Abstract

Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells. Over the past few years there has been significant progress in identifying the components of the telomerase holoenzyme complex and the proteins that associate with telomeres, in order to elucidate mechanisms of telomere length regulation. This review covers recent advances in the field including the use of telomerase in cancer diagnostics and an overview of anti-telomerase cancer therapeutic approaches.

Original language	English (US)
Pages (from-to)	677-685
Number of pages	9
Journal	Human molecular genetics
Volume	10
Issue number	7
DOIs	https://doi.org/10.1093/hmg/10.7.677
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1093/hmg/10.7.677

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AU - Zou, Ying

AU - Hiyama, Eiso

AU - Wright, Woodring E.

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AB - Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells. Over the past few years there has been significant progress in identifying the components of the telomerase holoenzyme complex and the proteins that associate with telomeres, in order to elucidate mechanisms of telomere length regulation. This review covers recent advances in the field including the use of telomerase in cancer diagnostics and an overview of anti-telomerase cancer therapeutic approaches.

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Telomerase and cancer

Abstract

ASJC Scopus subject areas

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