Techniques to distinguish the ureter from the uterine artery in photoacoustic-guided hysterectomies

Alycen Wiacek, Karen C. Wang, Muyinatu A. Lediju Bell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Gynecologic surgery requires the clamping, cauterization, and transection of arteries that lie within mil- limeters of the ureter, posing significant potential risk for ureteral injury. By leveraging the optical absorption properties of hemoglobin and methylene blue (an FDA-approved contrast agent), we propose intraoperative pho- toacoustic imaging during hysterectomies to simultaneously visualize the uterine arteries and ureter, respectively. Three experiments were performed to test the feasibility of a spectroscopic system aimed at intraoperative visual- ization. At 690 nm, the contrast from blood and urine mixed with 200 uM methylene blue was 13.83 dB and 11.06 dB, respectively, representing a 2.77 dB contrast difference. Conversely, at 750 nm, the contrast from blood was similar (14.61 dB), and the contrast from urine mixed with 200 uM methylene blue decreased to 1.74 dB, which produced a greater contrast difference of 12.87 dB. When tissue was added, similar contrast differences were observed at these wavelengths. Finally, a laparoscopic tool was additionally visualized in real time in proximity to the ureter and uterine arteries, which supports the feasibility of a spectroscopic photoacoustic approach to differentiating the ureter from the uterine arteries in relationship to a laparoscopic tool during hysterectomies.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2019
EditorsLihong V. Wang, Alexander A. Oraevsky
PublisherSPIE
ISBN (Electronic)9781510623989
DOIs
StatePublished - 2019
EventPhotons Plus Ultrasound: Imaging and Sensing 2019 - San Francisco, United States
Duration: Feb 3 2019Feb 6 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10878
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2019
Country/TerritoryUnited States
CitySan Francisco
Period2/3/192/6/19

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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