Technique of injection into the spinal cord of monkeys

Randhir P. Sinha; Thomas B. Ducker; Phanor L. Perot

doi:10.1016/0022-4804(73)90122-4

Technique of injection into the spinal cord of monkeys

Randhir P. Sinha, Thomas B. Ducker, Phanor L. Perot

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Microintramedullary injection into the spinal cord was studied in the primate. A rate of 0.005-0.015 ml/min in the dosage of 0.025-0.035 ml/cm cord diameter in each side showed no significant alteration in the clinical condition of the animal in cord function except for minor alterations of somatosensory evoked potentials. No systemic effects were noted. The method of local drug injection may prove to be an effective way of obtaining a high local concentration of agents capable of modifying the spinal cord tissue response to trauma.

Original language	English (US)
Pages (from-to)	518-523
Number of pages	6
Journal	Journal of Surgical Research
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/0022-4804(73)90122-4
State	Published - Jun 1973

ASJC Scopus subject areas

Surgery

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10.1016/0022-4804(73)90122-4

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AU - Ducker, Thomas B.

AU - Perot, Phanor L.

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N2 - Microintramedullary injection into the spinal cord was studied in the primate. A rate of 0.005-0.015 ml/min in the dosage of 0.025-0.035 ml/cm cord diameter in each side showed no significant alteration in the clinical condition of the animal in cord function except for minor alterations of somatosensory evoked potentials. No systemic effects were noted. The method of local drug injection may prove to be an effective way of obtaining a high local concentration of agents capable of modifying the spinal cord tissue response to trauma.

AB - Microintramedullary injection into the spinal cord was studied in the primate. A rate of 0.005-0.015 ml/min in the dosage of 0.025-0.035 ml/cm cord diameter in each side showed no significant alteration in the clinical condition of the animal in cord function except for minor alterations of somatosensory evoked potentials. No systemic effects were noted. The method of local drug injection may prove to be an effective way of obtaining a high local concentration of agents capable of modifying the spinal cord tissue response to trauma.

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Technique of injection into the spinal cord of monkeys

Abstract

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