Microintramedullary injection into the spinal cord was studied in the primate. A rate of 0.005-0.015 ml/min in the dosage of 0.025-0.035 ml/cm cord diameter in each side showed no significant alteration in the clinical condition of the animal in cord function except for minor alterations of somatosensory evoked potentials. No systemic effects were noted. The method of local drug injection may prove to be an effective way of obtaining a high local concentration of agents capable of modifying the spinal cord tissue response to trauma.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Surgical Research|
|State||Published - Jun 1973|
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