Technical innovation in dynamic contrast-enhanced magnetic resonance imaging of musculoskeletal tumors: An MR angiographic sequence using a sparse k-space sampling strategy

Laura M. Fayad, Charles Mugera, Theodoros Soldatos, Aaron Flammang, Filippo Del Grande

Research output: Contribution to journalArticle

Abstract

Objective: We demonstrate the clinical use of an MR angiography sequence performed with sparse k-space sampling (MRA), as a method for dynamic contrast-enhanced (DCE)-MRI, and apply it to the assessment of sarcomas for treatment response. Materials and methods: Three subjects with sarcomas (2 with osteosarcoma, 1 with high-grade soft tissue sarcomas) underwent MRI after neoadjuvant therapy/prior to surgery, with conventional MRI (T1-weighted, fluid-sensitive, static post-contrast T1-weighted sequences) and DCE-MRI (MRA, time resolution = 7-10 s, TR/TE 2.4/0.9 ms, FOV 40 cm2). Images were reviewed by two observers in consensus who recorded image quality (1 = diagnostic, no significant artifacts, 2 = diagnostic, <25 % artifacts, 3 = nondiagnostic) and contrast enhancement characteristics by static MRI (presence/absence of contrast enhancement, percentage of enhancement) and DCE-MRI (presence/absence of arterial enhancement with time-intensity curves). Results were compared with histological response (defined as <5 % viable tumor [soft tissue sarcoma] or <10 % [bone sarcoma] following resection). Results: Diagnostic quality for all conventional and DCE-MRI sequences was rated as 1. In 2 of the 3 sarcomas, there was good histological response (≤5 % viable tumor); in 1 there was poor response (50 % viable tumor). By static post-contrast T1-weighted sequences, there was enhancement in all sarcomas, regardless of response (up to >75 % with good response, >75 % with poor response). DCE-MRI findings were concordant with histological response (arterial enhancement with poor response, no arterial enhancement with good response). Conclusion: Unlike conventional DCE-MRI sequences, an MRA sequence with sparse k-space sampling is easily integrated into a routine musculoskeletal tumor MRI protocol, with high diagnostic quality. In this preliminary work, tumor enhancement characteristics by DCE-MRI were used to assess treatment response.

Original languageEnglish (US)
Pages (from-to)993-1000
Number of pages8
JournalSkeletal Radiology
Volume42
Issue number7
DOIs
StatePublished - Jul 1 2013

Keywords

  • Dynamic contrast-enhanced MRI
  • MR angiography
  • Musculoskeletal
  • Sarcoma
  • Tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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