Technical Advances in Rhinologic Basic Science Research

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic rhinosinusitis (CRS) is the single most common self-reported chronic health condition in the United States and is estimated to affect 16% of the adult population annually. Despite the prevalence of this disease, there still exists an incomplete understanding of CRS pathophysiology. In this review, the authors highlight technological advances in rhinology: real-time polymerase chain reaction, epithelial cell culture, flow cytometry, genomics/single-nucleotide polymorphism detection, microarrays, and genetic/nongenetic animal models of sinusitis. The purpose of this review is to describe these methodologies and their contributions toward achieving a better understanding of CRS.

Original languageEnglish (US)
Pages (from-to)867-881
Number of pages15
JournalOtolaryngologic Clinics of North America
Volume42
Issue number5
DOIs
StatePublished - Oct 2009

Keywords

  • Animal models
  • Chronic rhinosinusitis
  • Flow cytometry
  • Microarray
  • Polymorphisms
  • Real-time PCR
  • Sinonasal epithelial cells

ASJC Scopus subject areas

  • Otorhinolaryngology

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