TY - JOUR
T1 - Tear production in vitamin a-responsive xerophthalmia
AU - Sommer, Alfred
AU - Emran, Nani
N1 - Funding Information:
The Nutritional Blindness Prevention Project is a joint undertaking of the Government of Indonesia and Helen Keller International (HKI), with substantial funding from the Office of Nutrition, United States Agency for International Development (USAID). Preparation of this report was carried out under Co-operative Agreement AID/DSAN-CA-0267-931-0045 between the Office of Nutrition, USAID, and ICEPO.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1982/1
Y1 - 1982/1
N2 - Schirmer tests showed decreased tearing (<15 mm of wetting) in 32 of 54 eyes (59%) of a representative group of patients with corneal xerophthalmia but in only four of 60 eyes (7%) of age-, sex-, and neighborhood-matched controls (P<.001). The occurrence of decreased tearing was directly related to protein status: eight of 18 eyes (44%) of children with serum transferrin levels below 50 mg/100 ml but only 13 of 62 eyes (21%) of children with higher levels produced less than 15 mm of wetting (P<.O1). Among otherwise well-nourished children, the occurrence of decreased tearing was directly related to the severity of xerophthalmia and thus to vitamin A status. We found decreased tearing in eight of 86 eyes (9%) of a group of unpaired controls, in nine of 38 eyes (24%) of children with conjunctival xerosis, and in 17 of 62 eyes (27%) of children with corneal involvement (P<0.1).
AB - Schirmer tests showed decreased tearing (<15 mm of wetting) in 32 of 54 eyes (59%) of a representative group of patients with corneal xerophthalmia but in only four of 60 eyes (7%) of age-, sex-, and neighborhood-matched controls (P<.001). The occurrence of decreased tearing was directly related to protein status: eight of 18 eyes (44%) of children with serum transferrin levels below 50 mg/100 ml but only 13 of 62 eyes (21%) of children with higher levels produced less than 15 mm of wetting (P<.O1). Among otherwise well-nourished children, the occurrence of decreased tearing was directly related to the severity of xerophthalmia and thus to vitamin A status. We found decreased tearing in eight of 86 eyes (9%) of a group of unpaired controls, in nine of 38 eyes (24%) of children with conjunctival xerosis, and in 17 of 62 eyes (27%) of children with corneal involvement (P<0.1).
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U2 - 10.1016/0002-9394(82)90703-6
DO - 10.1016/0002-9394(82)90703-6
M3 - Article
C2 - 7065090
AN - SCOPUS:0020061740
VL - 93
SP - 84
EP - 87
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 1
ER -