TDP-43 toxicity and the usefulness of junk

Shuying Sun, Don W. Cleveland

Research output: Contribution to journalArticle


A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.

Original languageEnglish (US)
Pages (from-to)1289-1291
Number of pages3
JournalNature genetics
Issue number12
StatePublished - Dec 1 2012


ASJC Scopus subject areas

  • Genetics

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