Abstract
A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.
Original language | English (US) |
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Pages (from-to) | 1289-1291 |
Number of pages | 3 |
Journal | Nature genetics |
Volume | 44 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2012 |
ASJC Scopus subject areas
- Genetics