TDP-43 toxicity and the usefulness of junk

Shuying Sun, Don W. Cleveland

Research output: Contribution to journalArticle

Abstract

A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.

Original languageEnglish (US)
Pages (from-to)1289-1291
Number of pages3
JournalNature Genetics
Volume44
Issue number12
DOIs
StatePublished - Dec 2012
Externally publishedYes

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RNA
lariat debranching enzyme

ASJC Scopus subject areas

  • Genetics

Cite this

TDP-43 toxicity and the usefulness of junk. / Sun, Shuying; Cleveland, Don W.

In: Nature Genetics, Vol. 44, No. 12, 12.2012, p. 1289-1291.

Research output: Contribution to journalArticle

Sun, Shuying ; Cleveland, Don W. / TDP-43 toxicity and the usefulness of junk. In: Nature Genetics. 2012 ; Vol. 44, No. 12. pp. 1289-1291.
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