TCF1 and β-catenin regulate T cell development and function

Qing Yu, Archna Sharma, Jyoti Misra Sen

Research output: Contribution to journalArticlepeer-review

Abstract

T cell factor-1 (TCF1) critically regulates T cell development. However, signals that control TCF1 function in developing and mature T cells remain unknown. TCF1 along with β-catenin activates gene transcription and in cooperation with Groucho family of proteins mediates gene repression. It has been established that the β-catenin-dependent gene expression is often downstream of the canonical Wnt signaling pathway. We have genetically manipulated the β-catenin gene and generated mutant mice that have shown an essential role for β-catenin and TCF1 during pre-T cell receptor (TCR) and TCR-dependent stages of T cell development. We have also demonstrated a function for TCF1 and β-catenin downstream of TCR signaling in the differentiation of mature CD4 T cells into T helper lineages.

Original languageEnglish (US)
Pages (from-to)45-55
Number of pages11
JournalImmunologic Research
Volume47
Issue number1-3
DOIs
StatePublished - Jul 2010
Externally publishedYes

Keywords

  • β-Catenin
  • β-Selection
  • CD4 T helper cell differentiation
  • Positive selection
  • T cell development
  • T cell factor-1

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Fingerprint Dive into the research topics of 'TCF1 and β-catenin regulate T cell development and function'. Together they form a unique fingerprint.

Cite this