TCF1 and β-catenin regulate T cell development and function

Qing Yu, Archna Sharma, Jyoti Misra Sen

Research output: Contribution to journalArticle

Abstract

T cell factor-1 (TCF1) critically regulates T cell development. However, signals that control TCF1 function in developing and mature T cells remain unknown. TCF1 along with β-catenin activates gene transcription and in cooperation with Groucho family of proteins mediates gene repression. It has been established that the β-catenin-dependent gene expression is often downstream of the canonical Wnt signaling pathway. We have genetically manipulated the β-catenin gene and generated mutant mice that have shown an essential role for β-catenin and TCF1 during pre-T cell receptor (TCR) and TCR-dependent stages of T cell development. We have also demonstrated a function for TCF1 and β-catenin downstream of TCR signaling in the differentiation of mature CD4 T cells into T helper lineages.

Original languageEnglish (US)
Pages (from-to)45-55
Number of pages11
JournalImmunologic Research
Volume47
Issue number1-3
DOIs
StatePublished - Jul 2010
Externally publishedYes

Fingerprint

T Cell Transcription Factor 1
Catenins
T-Lymphocytes
T-Cell Antigen Receptor
Wnt Signaling Pathway
Genes
Gene Expression
Proteins

Keywords

  • β-Catenin
  • β-Selection
  • CD4 T helper cell differentiation
  • Positive selection
  • T cell development
  • T cell factor-1

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

TCF1 and β-catenin regulate T cell development and function. / Yu, Qing; Sharma, Archna; Sen, Jyoti Misra.

In: Immunologic Research, Vol. 47, No. 1-3, 07.2010, p. 45-55.

Research output: Contribution to journalArticle

Yu, Qing ; Sharma, Archna ; Sen, Jyoti Misra. / TCF1 and β-catenin regulate T cell development and function. In: Immunologic Research. 2010 ; Vol. 47, No. 1-3. pp. 45-55.
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