Abstract
T cell factor-1 (TCF1) critically regulates T cell development. However, signals that control TCF1 function in developing and mature T cells remain unknown. TCF1 along with β-catenin activates gene transcription and in cooperation with Groucho family of proteins mediates gene repression. It has been established that the β-catenin-dependent gene expression is often downstream of the canonical Wnt signaling pathway. We have genetically manipulated the β-catenin gene and generated mutant mice that have shown an essential role for β-catenin and TCF1 during pre-T cell receptor (TCR) and TCR-dependent stages of T cell development. We have also demonstrated a function for TCF1 and β-catenin downstream of TCR signaling in the differentiation of mature CD4 T cells into T helper lineages.
Original language | English (US) |
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Pages (from-to) | 45-55 |
Number of pages | 11 |
Journal | Immunologic Research |
Volume | 47 |
Issue number | 1-3 |
DOIs | |
State | Published - Jul 2010 |
Externally published | Yes |
Keywords
- β-Catenin
- β-Selection
- CD4 T helper cell differentiation
- Positive selection
- T cell development
- T cell factor-1
ASJC Scopus subject areas
- Immunology
- General Medicine