TY - JOUR
T1 - TBARS and cardiovascular disease in a population-based sample
AU - Schisterman, E. F.
AU - Faraggi, D.
AU - Browne, R.
AU - Freudenheim, J.
AU - Dorn, J.
AU - Muti, P.
AU - Armstrong, D.
AU - Reiser, B.
AU - Trevisan, M.
PY - 2001
Y1 - 2001
N2 - Background: Oxygen radicals might play a crucial role in the pathogenesis of various diseases, including atherosclerosis. Thiobarbituric acid reaction substances (TBARS), a biomarker of oxidative stress, have been proposed as a summary measure of total circulating oxidation. However, there is no strong indication that circulating levels of TBARS are increased in patients with atherosclerosis. Design: We evaluated the relation between TBARS and cardiovascular disease (CVD) in a cross-sectional random sample of white men and women from Buffalo, New York. Methods: Logistic regression was used to estimate the risk associated with high levels of TBARS. The area under the ROC curve was used to evaluate the discriminating power of TBARS. Results: After adjusting for age and gender, TBARS levels were significantly higher in those with prevalent CVD (OR= 1.73, 95% Cl = 1.32-2.38), compared to those without a CVD diagnosis. These OR were almost 50% higher after correcting for measurement error (ME) (OR=1.93, 95% Cl=1.07-3.40). The area under the ROC curve was 0.69 (95% Cl=0.62-0.77) and when corrected for ME reached 0.80 (95% Cl=0.65-0.89). Conclusions: Our results indicate that elevated levels of TBARS were associated with increase risk of the prevalence of CVD, but this effect was no longer significant after adjusting for glucose.
AB - Background: Oxygen radicals might play a crucial role in the pathogenesis of various diseases, including atherosclerosis. Thiobarbituric acid reaction substances (TBARS), a biomarker of oxidative stress, have been proposed as a summary measure of total circulating oxidation. However, there is no strong indication that circulating levels of TBARS are increased in patients with atherosclerosis. Design: We evaluated the relation between TBARS and cardiovascular disease (CVD) in a cross-sectional random sample of white men and women from Buffalo, New York. Methods: Logistic regression was used to estimate the risk associated with high levels of TBARS. The area under the ROC curve was used to evaluate the discriminating power of TBARS. Results: After adjusting for age and gender, TBARS levels were significantly higher in those with prevalent CVD (OR= 1.73, 95% Cl = 1.32-2.38), compared to those without a CVD diagnosis. These OR were almost 50% higher after correcting for measurement error (ME) (OR=1.93, 95% Cl=1.07-3.40). The area under the ROC curve was 0.69 (95% Cl=0.62-0.77) and when corrected for ME reached 0.80 (95% Cl=0.65-0.89). Conclusions: Our results indicate that elevated levels of TBARS were associated with increase risk of the prevalence of CVD, but this effect was no longer significant after adjusting for glucose.
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Free radicals
KW - Random measurement error
KW - ROC curve
KW - TBARS
UR - http://www.scopus.com/inward/record.url?scp=0034862703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034862703&partnerID=8YFLogxK
U2 - 10.1097/00043798-200108000-00006
DO - 10.1097/00043798-200108000-00006
M3 - Article
C2 - 11551000
AN - SCOPUS:0034862703
SN - 1350-6277
VL - 8
SP - 219
EP - 225
JO - Journal of Cardiovascular Risk
JF - Journal of Cardiovascular Risk
IS - 4
ER -