Tazarotene cream for the treatment of facial photodamage: A multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks

Sewon Kang, James J. Leyden, Nicholas J. Lowe, Jean Paul Ortonne, Tania J. Phillips, Gerald D. Weinstein, Jag Bhawan, Deborah A. Lew-Kaya, Richard M. Matsumoto, John Sefton, Patricia S. Walker, John R. Gibson

Research output: Contribution to journalArticle

Abstract

Objective: To assess the safety and efficacy of 4 concentrations of tazarotene cream in the treatment of facial photodamage. Design: Prospective weekly multicenter, investigator-masked, randomized, parallel-group study. Setting: University hospitals and clinical research centers. Patients: Three hundred forty-nine subjects with facial photodamage. Intervention: Daily topical application of tazarotene cream (0.01%, 0.025%, 0.05%, and 0.1%) compared with its vehicle and with 0.05% tretinoin emollient cream. Results: Tazarotene cream and tretinoin cream significantly improved mottled hyperpigmentation and fine wrinkles. At week 24, treatment success rates based on global responses were 67% (39 of 58 subjects) with 0.1% tazarotene, 52% (30 of 58 subjects) with 0.05% tazarotene, 36% (21 of 58 subjects) with 0.025% tazarotene, 41% (24 of 59 subjects) with 0.01% tazarotene, 55% (32 of 58 subjects) with 0.05% tretinoin, and 22% (13 of 58 subjects) with vehicle. Local adverse events, although more frequent with tazarotene at higher concentrations, were generally mild to moderate. Conclusions: Tazarotene in a cream formulation is safe and is associated with positive changes in the treatment of photodamaged facial skin.

Original languageEnglish (US)
Pages (from-to)1597-1604
Number of pages8
JournalArchives of dermatology
Volume137
Issue number12
StatePublished - Dec 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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    Kang, S., Leyden, J. J., Lowe, N. J., Ortonne, J. P., Phillips, T. J., Weinstein, G. D., Bhawan, J., Lew-Kaya, D. A., Matsumoto, R. M., Sefton, J., Walker, P. S., & Gibson, J. R. (2001). Tazarotene cream for the treatment of facial photodamage: A multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks. Archives of dermatology, 137(12), 1597-1604.