Taxanes: A new class of antitumor agents

M. T. Huizing, V. H Sewberath Misser, R. C. Pieters, W. W. ten Bokkel Huinink, C. H N Veenhof, J. B. Vermorken, H. M. Pinedo, J. H. Beijnen

Research output: Contribution to journalArticlepeer-review

Abstract

Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. Paclitaxel, the first agent in this group to become available, was isolated from the Pacific yew, Taxus brevifolia, in 1971. In preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review deals with the physicochemical properties, pharmacology, and results of preclinical and clinical trials of the taxanes.

Original languageEnglish (US)
Pages (from-to)381-404
Number of pages24
JournalCancer Investigation
Volume13
Issue number4
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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