Tauroursodeoxycholic acid is less damaging than taurochenodeoxycholic acid to the gastric and esophageal mucosa

Keith D. Lillemoe, George W. Kidder, John Harmon, Thomas R. Gadacz, Lawrence F. Johnson, Ralph M. Bunte, Alan F. Hofmann

Research output: Contribution to journalArticle

Abstract

Bile acids are capable of disrupting the gastric and esophageal mucosal barriers and are known to differ in their ability to injure these mucosae. Two bile acids, chenodeoxycholic and its 7-B epimer, ursodeoxycholic, that are being used to dissolve gallbladder stones were evaluated for their damaging effects on experimental preparations of the esophageal (rabbit) and gastric (dog) mucosa. Damage was assessed by measuring indices of mucosal barrier function, including net acid flux, potential difference, and tissue resistance, before and after exposure to the taurine conjugates of these bile acids. In both the esophageal and gastric mucosa, tauroursodeoxycholic acid caused significantly less disruption of barrier function than taurochenodeoxycholic acid. These results demonstrate that minor differences in conjugated bile acid structure can cause major changes in the effects of bile acids on the upper gastrointestinal mucosa and that ursodeoxycholic acid may be the preferred bile acid for oral ingestion to dissolve gallbladder stones.

Original languageEnglish (US)
Pages (from-to)359-364
Number of pages6
JournalDigestive Diseases and Sciences
Volume28
Issue number4
DOIs
StatePublished - Apr 1983
Externally publishedYes

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Taurochenodeoxycholic Acid
Gastric Mucosa
Bile Acids and Salts
Gallbladder
Mucous Membrane
Ursodeoxycholic Acid
Taurine
tauroursodeoxycholic acid
Esophageal Mucosa
Stomach
Eating
Dogs
Rabbits
Acids

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Tauroursodeoxycholic acid is less damaging than taurochenodeoxycholic acid to the gastric and esophageal mucosa. / Lillemoe, Keith D.; Kidder, George W.; Harmon, John; Gadacz, Thomas R.; Johnson, Lawrence F.; Bunte, Ralph M.; Hofmann, Alan F.

In: Digestive Diseases and Sciences, Vol. 28, No. 4, 04.1983, p. 359-364.

Research output: Contribution to journalArticle

Lillemoe, Keith D. ; Kidder, George W. ; Harmon, John ; Gadacz, Thomas R. ; Johnson, Lawrence F. ; Bunte, Ralph M. ; Hofmann, Alan F. / Tauroursodeoxycholic acid is less damaging than taurochenodeoxycholic acid to the gastric and esophageal mucosa. In: Digestive Diseases and Sciences. 1983 ; Vol. 28, No. 4. pp. 359-364.
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