Tau pathology in cognitively normal older adults

Jacob Ziontz, Murat Bilgel, Andrea T. Shafer, Abhay R Moghekar, Wendy Elkins, Jessica Helphrey, Gabriela Gomez, Danielle June, Michael A. McDonald, Robert F Dannals, Babak Behnam Azad, Luigi Ferrucci, Dean Foster Wong, Susan M. Resnick

Research output: Contribution to journalArticle

Abstract

Introduction: Tau pathology, a hallmark of Alzheimer's disease, is observed in the brains of virtually all individuals over 70 years. Methods: Using 18F-AV-1451 (18F-flortaucipir) positron emission tomography, we evaluated tau pathology in 54 cognitively normal participants (mean age: 77.5 years, SD: 8.9) from the Baltimore Longitudinal Study of Aging. We assessed associations between positron emission tomography signal and age, sex, race, and amyloid positivity. We investigated relationships between regional signal and retrospective rates of change in regional volumes and cognitive function adjusting for age, sex, and amyloid status. Results: Greater age, male sex, black race, and amyloid positivity were associated with higher 18F-AV-1451 retention in distinct brain regions. Retention in the entorhinal cortex was associated with lower entorhinal volume (β = −1.124, SE = 0.485, P =.025) and a steeper decline in memory performance (β = −0.086, SE = 0.039, P =.029). Discussion: Assessment of medial temporal tau pathology will provide insights into early structural brain changes associated with later cognitive impairment and Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)637-645
Number of pages9
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
StatePublished - Dec 1 2019

Fingerprint

Amyloid
Pathology
Positron-Emission Tomography
Alzheimer Disease
Brain
Baltimore
Entorhinal Cortex
Cognition
Longitudinal Studies
Retention (Psychology)

Keywords

  • AV-1451
  • Cognition
  • Cognitively normal
  • Flortaucipir
  • FTP
  • Longitudinal
  • PET
  • T807
  • Tau
  • Volume

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Tau pathology in cognitively normal older adults. / Ziontz, Jacob; Bilgel, Murat; Shafer, Andrea T.; Moghekar, Abhay R; Elkins, Wendy; Helphrey, Jessica; Gomez, Gabriela; June, Danielle; McDonald, Michael A.; Dannals, Robert F; Behnam Azad, Babak; Ferrucci, Luigi; Wong, Dean Foster; Resnick, Susan M.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 01.12.2019, p. 637-645.

Research output: Contribution to journalArticle

Ziontz, J, Bilgel, M, Shafer, AT, Moghekar, AR, Elkins, W, Helphrey, J, Gomez, G, June, D, McDonald, MA, Dannals, RF, Behnam Azad, B, Ferrucci, L, Wong, DF & Resnick, SM 2019, 'Tau pathology in cognitively normal older adults', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 637-645. https://doi.org/10.1016/j.dadm.2019.07.007
Ziontz, Jacob ; Bilgel, Murat ; Shafer, Andrea T. ; Moghekar, Abhay R ; Elkins, Wendy ; Helphrey, Jessica ; Gomez, Gabriela ; June, Danielle ; McDonald, Michael A. ; Dannals, Robert F ; Behnam Azad, Babak ; Ferrucci, Luigi ; Wong, Dean Foster ; Resnick, Susan M. / Tau pathology in cognitively normal older adults. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 ; Vol. 11. pp. 637-645.
@article{d2a75cf3eece4262b72d5be4adf0ebae,
title = "Tau pathology in cognitively normal older adults",
abstract = "Introduction: Tau pathology, a hallmark of Alzheimer's disease, is observed in the brains of virtually all individuals over 70 years. Methods: Using 18F-AV-1451 (18F-flortaucipir) positron emission tomography, we evaluated tau pathology in 54 cognitively normal participants (mean age: 77.5 years, SD: 8.9) from the Baltimore Longitudinal Study of Aging. We assessed associations between positron emission tomography signal and age, sex, race, and amyloid positivity. We investigated relationships between regional signal and retrospective rates of change in regional volumes and cognitive function adjusting for age, sex, and amyloid status. Results: Greater age, male sex, black race, and amyloid positivity were associated with higher 18F-AV-1451 retention in distinct brain regions. Retention in the entorhinal cortex was associated with lower entorhinal volume (β = −1.124, SE = 0.485, P =.025) and a steeper decline in memory performance (β = −0.086, SE = 0.039, P =.029). Discussion: Assessment of medial temporal tau pathology will provide insights into early structural brain changes associated with later cognitive impairment and Alzheimer's disease.",
keywords = "AV-1451, Cognition, Cognitively normal, Flortaucipir, FTP, Longitudinal, PET, T807, Tau, Volume",
author = "Jacob Ziontz and Murat Bilgel and Shafer, {Andrea T.} and Moghekar, {Abhay R} and Wendy Elkins and Jessica Helphrey and Gabriela Gomez and Danielle June and McDonald, {Michael A.} and Dannals, {Robert F} and {Behnam Azad}, Babak and Luigi Ferrucci and Wong, {Dean Foster} and Resnick, {Susan M.}",
year = "2019",
month = "12",
day = "1",
doi = "10.1016/j.dadm.2019.07.007",
language = "English (US)",
volume = "11",
pages = "637--645",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Tau pathology in cognitively normal older adults

AU - Ziontz, Jacob

AU - Bilgel, Murat

AU - Shafer, Andrea T.

AU - Moghekar, Abhay R

AU - Elkins, Wendy

AU - Helphrey, Jessica

AU - Gomez, Gabriela

AU - June, Danielle

AU - McDonald, Michael A.

AU - Dannals, Robert F

AU - Behnam Azad, Babak

AU - Ferrucci, Luigi

AU - Wong, Dean Foster

AU - Resnick, Susan M.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Introduction: Tau pathology, a hallmark of Alzheimer's disease, is observed in the brains of virtually all individuals over 70 years. Methods: Using 18F-AV-1451 (18F-flortaucipir) positron emission tomography, we evaluated tau pathology in 54 cognitively normal participants (mean age: 77.5 years, SD: 8.9) from the Baltimore Longitudinal Study of Aging. We assessed associations between positron emission tomography signal and age, sex, race, and amyloid positivity. We investigated relationships between regional signal and retrospective rates of change in regional volumes and cognitive function adjusting for age, sex, and amyloid status. Results: Greater age, male sex, black race, and amyloid positivity were associated with higher 18F-AV-1451 retention in distinct brain regions. Retention in the entorhinal cortex was associated with lower entorhinal volume (β = −1.124, SE = 0.485, P =.025) and a steeper decline in memory performance (β = −0.086, SE = 0.039, P =.029). Discussion: Assessment of medial temporal tau pathology will provide insights into early structural brain changes associated with later cognitive impairment and Alzheimer's disease.

AB - Introduction: Tau pathology, a hallmark of Alzheimer's disease, is observed in the brains of virtually all individuals over 70 years. Methods: Using 18F-AV-1451 (18F-flortaucipir) positron emission tomography, we evaluated tau pathology in 54 cognitively normal participants (mean age: 77.5 years, SD: 8.9) from the Baltimore Longitudinal Study of Aging. We assessed associations between positron emission tomography signal and age, sex, race, and amyloid positivity. We investigated relationships between regional signal and retrospective rates of change in regional volumes and cognitive function adjusting for age, sex, and amyloid status. Results: Greater age, male sex, black race, and amyloid positivity were associated with higher 18F-AV-1451 retention in distinct brain regions. Retention in the entorhinal cortex was associated with lower entorhinal volume (β = −1.124, SE = 0.485, P =.025) and a steeper decline in memory performance (β = −0.086, SE = 0.039, P =.029). Discussion: Assessment of medial temporal tau pathology will provide insights into early structural brain changes associated with later cognitive impairment and Alzheimer's disease.

KW - AV-1451

KW - Cognition

KW - Cognitively normal

KW - Flortaucipir

KW - FTP

KW - Longitudinal

KW - PET

KW - T807

KW - Tau

KW - Volume

UR - http://www.scopus.com/inward/record.url?scp=85071872763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071872763&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2019.07.007

DO - 10.1016/j.dadm.2019.07.007

M3 - Article

C2 - 31517026

AN - SCOPUS:85071872763

VL - 11

SP - 637

EP - 645

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

ER -