Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve

K. U. Loeffler, D. P. Edward, M. O.M. Tso

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. To characterize the constituents of corpora amylacea in the human retina and optic nerve. Methods. Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein. Results. Consistent anti-tau-2 immunoreactivity was noted in the corpora amylacea in the retina, optic nerve, and brain tissue, albeit with variations in pattern and intensity of staining. No immunoreactivity was observed with antibodies anti-tau 1 and anti-amyloid precursor protein. Conclusion. Our findings suggest the accumulation of possibly abnormal tau-2 within the corpora amylacea, which may be either astrocytic or axonal in origin.

Original languageEnglish (US)
Pages (from-to)2600-2603
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume34
Issue number8
StatePublished - 1993
Externally publishedYes

Keywords

  • corpora amylacea
  • immunohistochemistry
  • optic nerve
  • retina
  • ultrastructure

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve'. Together they form a unique fingerprint.

Cite this