Abstract
We employed a structured interview to retrospectively study tastes and vomiting associated with the parenteral components of cyclophosphamide, methotrexate, and 5-FU in 45 patients with stage II-IV breast cancer. Sixteen patients (36%) reported tastes which generally occurred in each cycle within 30 minutes of parenteral drug administration, lasted ≤ hour, and were bitter. Five patients recalled that tastes seemed to produce vomiting. Tasting was significantly associated with postchemotherapy (P <0.01) but not anticipatory vomiting. Employing logistic regression techniques, tasting did not significantly improve prediction of anticipatory vomiting by postchemotherapy vomiting. Tastes may be produced by the action of plasma or salivary cyclophosphamide, methotrexate, and 5-FU on taste buds. While tastes might cause some vomiting, they are not necessary for it. Because this was a retrospective study with a small sample, these findings require confirmation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1249-1251 |
| Number of pages | 3 |
| Journal | Cancer Treatment Reports |
| Volume | 69 |
| Issue number | 11 |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Tastes associated with parenteral chemotherapy for breast cancer. / Fetting, J. H.; Wilcox, P. M.; Sheidler, V. R.; Enterline, J. P.; Donehower, R. C.; Grochow, L. B.
In: Cancer Treatment Reports, Vol. 69, No. 11, 1985, p. 1249-1251.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tastes associated with parenteral chemotherapy for breast cancer
AU - Fetting, J. H.
AU - Wilcox, P. M.
AU - Sheidler, V. R.
AU - Enterline, J. P.
AU - Donehower, R. C.
AU - Grochow, L. B.
PY - 1985
Y1 - 1985
N2 - We employed a structured interview to retrospectively study tastes and vomiting associated with the parenteral components of cyclophosphamide, methotrexate, and 5-FU in 45 patients with stage II-IV breast cancer. Sixteen patients (36%) reported tastes which generally occurred in each cycle within 30 minutes of parenteral drug administration, lasted ≤ hour, and were bitter. Five patients recalled that tastes seemed to produce vomiting. Tasting was significantly associated with postchemotherapy (P <0.01) but not anticipatory vomiting. Employing logistic regression techniques, tasting did not significantly improve prediction of anticipatory vomiting by postchemotherapy vomiting. Tastes may be produced by the action of plasma or salivary cyclophosphamide, methotrexate, and 5-FU on taste buds. While tastes might cause some vomiting, they are not necessary for it. Because this was a retrospective study with a small sample, these findings require confirmation.
AB - We employed a structured interview to retrospectively study tastes and vomiting associated with the parenteral components of cyclophosphamide, methotrexate, and 5-FU in 45 patients with stage II-IV breast cancer. Sixteen patients (36%) reported tastes which generally occurred in each cycle within 30 minutes of parenteral drug administration, lasted ≤ hour, and were bitter. Five patients recalled that tastes seemed to produce vomiting. Tasting was significantly associated with postchemotherapy (P <0.01) but not anticipatory vomiting. Employing logistic regression techniques, tasting did not significantly improve prediction of anticipatory vomiting by postchemotherapy vomiting. Tastes may be produced by the action of plasma or salivary cyclophosphamide, methotrexate, and 5-FU on taste buds. While tastes might cause some vomiting, they are not necessary for it. Because this was a retrospective study with a small sample, these findings require confirmation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022389394&partnerID=8YFLogxK
M3 - Article
C2 - 3841501
AN - SCOPUS:0022389394
VL - 69
SP - 1249
EP - 1251
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 11
ER -