Tastes associated with parenteral chemotherapy for breast cancer

J. H. Fetting, P. M. Wilcox, V. R. Sheidler, J. P. Enterline, R. C. Donehower, L. B. Grochow

Research output: Contribution to journalArticle

Abstract

We employed a structured interview to retrospectively study tastes and vomiting associated with the parenteral components of cyclophosphamide, methotrexate, and 5-FU in 45 patients with stage II-IV breast cancer. Sixteen patients (36%) reported tastes which generally occurred in each cycle within 30 minutes of parenteral drug administration, lasted ≤ hour, and were bitter. Five patients recalled that tastes seemed to produce vomiting. Tasting was significantly associated with postchemotherapy (P <0.01) but not anticipatory vomiting. Employing logistic regression techniques, tasting did not significantly improve prediction of anticipatory vomiting by postchemotherapy vomiting. Tastes may be produced by the action of plasma or salivary cyclophosphamide, methotrexate, and 5-FU on taste buds. While tastes might cause some vomiting, they are not necessary for it. Because this was a retrospective study with a small sample, these findings require confirmation.

Original languageEnglish (US)
Pages (from-to)1249-1251
Number of pages3
JournalCancer Treatment Reports
Volume69
Issue number11
StatePublished - 1985

Fingerprint

Vomiting
Anticipatory Vomiting
Breast Neoplasms
Drug Therapy
Methotrexate
Fluorouracil
Cyclophosphamide
Taste Buds
Retrospective Studies
Logistic Models
Interviews
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Fetting, J. H., Wilcox, P. M., Sheidler, V. R., Enterline, J. P., Donehower, R. C., & Grochow, L. B. (1985). Tastes associated with parenteral chemotherapy for breast cancer. Cancer Treatment Reports, 69(11), 1249-1251.

Tastes associated with parenteral chemotherapy for breast cancer. / Fetting, J. H.; Wilcox, P. M.; Sheidler, V. R.; Enterline, J. P.; Donehower, R. C.; Grochow, L. B.

In: Cancer Treatment Reports, Vol. 69, No. 11, 1985, p. 1249-1251.

Research output: Contribution to journalArticle

Fetting, JH, Wilcox, PM, Sheidler, VR, Enterline, JP, Donehower, RC & Grochow, LB 1985, 'Tastes associated with parenteral chemotherapy for breast cancer', Cancer Treatment Reports, vol. 69, no. 11, pp. 1249-1251.
Fetting JH, Wilcox PM, Sheidler VR, Enterline JP, Donehower RC, Grochow LB. Tastes associated with parenteral chemotherapy for breast cancer. Cancer Treatment Reports. 1985;69(11):1249-1251.
Fetting, J. H. ; Wilcox, P. M. ; Sheidler, V. R. ; Enterline, J. P. ; Donehower, R. C. ; Grochow, L. B. / Tastes associated with parenteral chemotherapy for breast cancer. In: Cancer Treatment Reports. 1985 ; Vol. 69, No. 11. pp. 1249-1251.
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AU - Wilcox, P. M.

AU - Sheidler, V. R.

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AU - Donehower, R. C.

AU - Grochow, L. B.

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