Taste-Potentiated Odor Conditioning

Impairment Produced by Infusion of an N-Methyl-D-Aspartate Antagonist Into Basolateral Amygdala

Tammy Hatfield, Michela Gallagher

Research output: Contribution to journalArticle

Abstract

Two experiments examined the effects of infusing an N -methyl-D-aspartate (NMDA) receptor antagonist, d -2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impaired in their acquisition of the potentiated learning to an odor cue. Expression of this learning and acquisition of a simple taste aversion remained intact following drug treatment. In Experiment 2, dose dependence and stereoselectivity were demonstrated for the antagonist compound. These results are consistent with previous studies demonstrating that either basolateral amygdala lesions, or treatment with NMDA antagonists, by other routes (systemic or intraventricular) produce selective deficits in taste-potentiated odor conditioning.

Original languageEnglish (US)
Pages (from-to)663-668
Number of pages6
JournalBehavioral Neuroscience
Volume109
Issue number4
StatePublished - Aug 1995
Externally publishedYes

Fingerprint

N-Methylaspartate
2-Amino-5-phosphonovalerate
Learning
N-Methyl-D-Aspartate Receptors
Automatic Data Processing
Cues
Therapeutics
Pharmaceutical Preparations
Conditioning (Psychology)
Odorants
Basolateral Nuclear Complex

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

@article{83c368e0b4f94d3fbf8a00d27f50d8db,
title = "Taste-Potentiated Odor Conditioning: Impairment Produced by Infusion of an N-Methyl-D-Aspartate Antagonist Into Basolateral Amygdala",
abstract = "Two experiments examined the effects of infusing an N -methyl-D-aspartate (NMDA) receptor antagonist, d -2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impaired in their acquisition of the potentiated learning to an odor cue. Expression of this learning and acquisition of a simple taste aversion remained intact following drug treatment. In Experiment 2, dose dependence and stereoselectivity were demonstrated for the antagonist compound. These results are consistent with previous studies demonstrating that either basolateral amygdala lesions, or treatment with NMDA antagonists, by other routes (systemic or intraventricular) produce selective deficits in taste-potentiated odor conditioning.",
author = "Tammy Hatfield and Michela Gallagher",
year = "1995",
month = "8",
language = "English (US)",
volume = "109",
pages = "663--668",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "4",

}

TY - JOUR

T1 - Taste-Potentiated Odor Conditioning

T2 - Impairment Produced by Infusion of an N-Methyl-D-Aspartate Antagonist Into Basolateral Amygdala

AU - Hatfield, Tammy

AU - Gallagher, Michela

PY - 1995/8

Y1 - 1995/8

N2 - Two experiments examined the effects of infusing an N -methyl-D-aspartate (NMDA) receptor antagonist, d -2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impaired in their acquisition of the potentiated learning to an odor cue. Expression of this learning and acquisition of a simple taste aversion remained intact following drug treatment. In Experiment 2, dose dependence and stereoselectivity were demonstrated for the antagonist compound. These results are consistent with previous studies demonstrating that either basolateral amygdala lesions, or treatment with NMDA antagonists, by other routes (systemic or intraventricular) produce selective deficits in taste-potentiated odor conditioning.

AB - Two experiments examined the effects of infusing an N -methyl-D-aspartate (NMDA) receptor antagonist, d -2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impaired in their acquisition of the potentiated learning to an odor cue. Expression of this learning and acquisition of a simple taste aversion remained intact following drug treatment. In Experiment 2, dose dependence and stereoselectivity were demonstrated for the antagonist compound. These results are consistent with previous studies demonstrating that either basolateral amygdala lesions, or treatment with NMDA antagonists, by other routes (systemic or intraventricular) produce selective deficits in taste-potentiated odor conditioning.

UR - http://www.scopus.com/inward/record.url?scp=0029131897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029131897&partnerID=8YFLogxK

M3 - Article

VL - 109

SP - 663

EP - 668

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 4

ER -