Taste-Potentiated Odor Conditioning: Impairment Produced by Infusion of an N-Methyl-D-Aspartate Antagonist Into Basolateral Amygdala

Tammy Hatfield, Michela Gallagher

Research output: Contribution to journalArticle

Abstract

Two experiments examined the effects of infusing an N -methyl-D-aspartate (NMDA) receptor antagonist, d -2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impaired in their acquisition of the potentiated learning to an odor cue. Expression of this learning and acquisition of a simple taste aversion remained intact following drug treatment. In Experiment 2, dose dependence and stereoselectivity were demonstrated for the antagonist compound. These results are consistent with previous studies demonstrating that either basolateral amygdala lesions, or treatment with NMDA antagonists, by other routes (systemic or intraventricular) produce selective deficits in taste-potentiated odor conditioning.

Original languageEnglish (US)
Pages (from-to)663-668
Number of pages6
JournalBehavioral Neuroscience
Volume109
Issue number4
DOIs
StatePublished - Aug 1995
Externally publishedYes

ASJC Scopus subject areas

  • Behavioral Neuroscience

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