Taste dysfunction in multiple sclerosis

Richard L. Doty, Isabelle A. Tourbier, Dzung L. Pham, Jennifer L. Cuzzocreo, Jayaram K. Udupa, Bilge Karacali, Evan Beals, Laura Fabius, Fidias E. Leon-Sarmiento, Gul Moonis, Taehoon Kim, Toru Mihama, Rena J. Geckle, David Mark Yousem

Research output: Contribution to journalArticle

Abstract

Empirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile of controls was 15.07 % for caffeine, 21.9 % for citric acid, 24.66 % for sucrose, and 31.50 % for NaCl. Such scores were inversely correlated with lesion volumes in the temporal, medial frontal, and superior frontal lobes, and with the number of lesions in the left and right superior frontal lobes, right anterior cingulate gyrus, and left parietal operculum. Regardless of the subject group, women outperformed men on the taste measures. These findings indicate that a sizable number of MS patients exhibit taste deficits that are associated with MS-related lesions throughout the brain.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalJournal of Neurology
DOIs
StateAccepted/In press - Jan 25 2016

Fingerprint

Multiple Sclerosis
Caffeine
Citric Acid
Sucrose
Frontal Lobe
Tongue
Accidental Falls
Taste Perception
Gyrus Cinguli
Brain
Myelin Sheath

Keywords

  • Chemosensory transduction
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Sex differences
  • Taste
  • Taste disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Doty, R. L., Tourbier, I. A., Pham, D. L., Cuzzocreo, J. L., Udupa, J. K., Karacali, B., ... Yousem, D. M. (Accepted/In press). Taste dysfunction in multiple sclerosis. Journal of Neurology, 1-12. https://doi.org/10.1007/s00415-016-8030-6

Taste dysfunction in multiple sclerosis. / Doty, Richard L.; Tourbier, Isabelle A.; Pham, Dzung L.; Cuzzocreo, Jennifer L.; Udupa, Jayaram K.; Karacali, Bilge; Beals, Evan; Fabius, Laura; Leon-Sarmiento, Fidias E.; Moonis, Gul; Kim, Taehoon; Mihama, Toru; Geckle, Rena J.; Yousem, David Mark.

In: Journal of Neurology, 25.01.2016, p. 1-12.

Research output: Contribution to journalArticle

Doty, RL, Tourbier, IA, Pham, DL, Cuzzocreo, JL, Udupa, JK, Karacali, B, Beals, E, Fabius, L, Leon-Sarmiento, FE, Moonis, G, Kim, T, Mihama, T, Geckle, RJ & Yousem, DM 2016, 'Taste dysfunction in multiple sclerosis', Journal of Neurology, pp. 1-12. https://doi.org/10.1007/s00415-016-8030-6
Doty RL, Tourbier IA, Pham DL, Cuzzocreo JL, Udupa JK, Karacali B et al. Taste dysfunction in multiple sclerosis. Journal of Neurology. 2016 Jan 25;1-12. https://doi.org/10.1007/s00415-016-8030-6
Doty, Richard L. ; Tourbier, Isabelle A. ; Pham, Dzung L. ; Cuzzocreo, Jennifer L. ; Udupa, Jayaram K. ; Karacali, Bilge ; Beals, Evan ; Fabius, Laura ; Leon-Sarmiento, Fidias E. ; Moonis, Gul ; Kim, Taehoon ; Mihama, Toru ; Geckle, Rena J. ; Yousem, David Mark. / Taste dysfunction in multiple sclerosis. In: Journal of Neurology. 2016 ; pp. 1-12.
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abstract = "Empirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile of controls was 15.07 {\%} for caffeine, 21.9 {\%} for citric acid, 24.66 {\%} for sucrose, and 31.50 {\%} for NaCl. Such scores were inversely correlated with lesion volumes in the temporal, medial frontal, and superior frontal lobes, and with the number of lesions in the left and right superior frontal lobes, right anterior cingulate gyrus, and left parietal operculum. Regardless of the subject group, women outperformed men on the taste measures. These findings indicate that a sizable number of MS patients exhibit taste deficits that are associated with MS-related lesions throughout the brain.",
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AU - Beals, Evan

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AU - Kim, Taehoon

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AU - Geckle, Rena J.

AU - Yousem, David Mark

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