Abstract
Empirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile of controls was 15.07 % for caffeine, 21.9 % for citric acid, 24.66 % for sucrose, and 31.50 % for NaCl. Such scores were inversely correlated with lesion volumes in the temporal, medial frontal, and superior frontal lobes, and with the number of lesions in the left and right superior frontal lobes, right anterior cingulate gyrus, and left parietal operculum. Regardless of the subject group, women outperformed men on the taste measures. These findings indicate that a sizable number of MS patients exhibit taste deficits that are associated with MS-related lesions throughout the brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-12 |
| Number of pages | 12 |
| Journal | Journal of Neurology |
| DOIs | |
| State | Accepted/In press - Jan 25 2016 |
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Keywords
- Chemosensory transduction
- Magnetic resonance imaging
- Multiple sclerosis
- Sex differences
- Taste
- Taste disorders
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Taste dysfunction in multiple sclerosis. / Doty, Richard L.; Tourbier, Isabelle A.; Pham, Dzung L.; Cuzzocreo, Jennifer L.; Udupa, Jayaram K.; Karacali, Bilge; Beals, Evan; Fabius, Laura; Leon-Sarmiento, Fidias E.; Moonis, Gul; Kim, Taehoon; Mihama, Toru; Geckle, Rena J.; Yousem, David Mark.
In: Journal of Neurology, 25.01.2016, p. 1-12.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Taste dysfunction in multiple sclerosis
AU - Doty, Richard L.
AU - Tourbier, Isabelle A.
AU - Pham, Dzung L.
AU - Cuzzocreo, Jennifer L.
AU - Udupa, Jayaram K.
AU - Karacali, Bilge
AU - Beals, Evan
AU - Fabius, Laura
AU - Leon-Sarmiento, Fidias E.
AU - Moonis, Gul
AU - Kim, Taehoon
AU - Mihama, Toru
AU - Geckle, Rena J.
AU - Yousem, David Mark
PY - 2016/1/25
Y1 - 2016/1/25
N2 - Empirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile of controls was 15.07 % for caffeine, 21.9 % for citric acid, 24.66 % for sucrose, and 31.50 % for NaCl. Such scores were inversely correlated with lesion volumes in the temporal, medial frontal, and superior frontal lobes, and with the number of lesions in the left and right superior frontal lobes, right anterior cingulate gyrus, and left parietal operculum. Regardless of the subject group, women outperformed men on the taste measures. These findings indicate that a sizable number of MS patients exhibit taste deficits that are associated with MS-related lesions throughout the brain.
AB - Empirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile of controls was 15.07 % for caffeine, 21.9 % for citric acid, 24.66 % for sucrose, and 31.50 % for NaCl. Such scores were inversely correlated with lesion volumes in the temporal, medial frontal, and superior frontal lobes, and with the number of lesions in the left and right superior frontal lobes, right anterior cingulate gyrus, and left parietal operculum. Regardless of the subject group, women outperformed men on the taste measures. These findings indicate that a sizable number of MS patients exhibit taste deficits that are associated with MS-related lesions throughout the brain.
KW - Chemosensory transduction
KW - Magnetic resonance imaging
KW - Multiple sclerosis
KW - Sex differences
KW - Taste
KW - Taste disorders
UR - http://www.scopus.com/inward/record.url?scp=84955316821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955316821&partnerID=8YFLogxK
U2 - 10.1007/s00415-016-8030-6
DO - 10.1007/s00415-016-8030-6
M3 - Article
C2 - 26810729
AN - SCOPUS:84955316821
SP - 1
EP - 12
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
ER -