Task-based evaluation of motion compensated reconstructed images using 4D channelized Hotelling observer in dual gated SPECT

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed a 4D SPECT image reconstruction method with respiratory motion (RM) and cardiac motion (CM) compensation, and evaluated its performance using a previously developed 4D channelized Hotelling observer (CHO) model for the task based evaluation of 4D medical images. A series of 4D XCAT (eXtended CArdiac Torso) phantoms with and without a regional CM abnormality was generated that divided a respiratory cycle into 24 frames and a cardiac cycle into 48 frames for each respiratory phase. Almost noise-free projection data were generated from the 1152 3D XCAT phantoms at each respiratory and cardiac (R&C) gated time frame using the SimSET simulation modeling a typical 99mTc Sestamibi gated myocardial perfusion (GMP) SPECT study. They were scaled and combined to form 6 equal-amplitude respiratory gates and 8 equal-time cardiac gates. Poisson noise was then added before image reconstruction using the 3D OS-EM with or without RM and CM compensation. Using a group-wise B-spline non-rigid image-based registration method, the deformation field (DF) of the RM were estimated and applied to each cardiac phase of the R&C gated SPECT images for RM correction. Then, the RM compensated GMP SPECT images were transformed using the estimated DF of the CM. The 2D reconstructed image slices were extracted and reorganized into a set of cine images and the space-time channels of the 4D CHO were applied to produce the space-time feature vectors to which the receiver operating characteristic (ROC) was applied and areas under the ROC curve (AUC) values calculated. The result demonstrated that the RM and CM compensated images showed drastically reduced noise level without blurring and its AUC values were significantly higher than those without compensation. We conclude that the RM and CM compensation allow significant reduction of image blurring and noise level in dual gated SPECT images resulting in significant improvement in detecting a regional CM abnormality using a 4D CHO model.

Original languageEnglish (US)
Title of host publication2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479905348
DOIs
StatePublished - Jan 1 2013
Event2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of
Duration: Oct 27 2013Nov 2 2013

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
CountryKorea, Republic of
CitySeoul
Period10/27/1311/2/13

Keywords

  • 4D image reconstruction
  • SPECT
  • channelized Hotelling observer
  • compensation
  • dual gating
  • respiratory and cardiac motion

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Task-based evaluation of motion compensated reconstructed images using 4D channelized Hotelling observer in dual gated SPECT'. Together they form a unique fingerprint.

  • Cite this

    Lee, T. S., Feng, T., Frey, E., & Tsui, B. M. W. (2013). Task-based evaluation of motion compensated reconstructed images using 4D channelized Hotelling observer in dual gated SPECT. In 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 [6829067] (IEEE Nuclear Science Symposium Conference Record). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2013.6829067