TY - JOUR
T1 - Targeting the tumour stroma to improve cancer therapy
AU - Valkenburg, Kenneth C.
AU - De Groot, Amber E.
AU - Pienta, Kenneth J.
N1 - Funding Information:
The work of K.C.P., K.C.V., and A.E.d.G. is supported by National Cancer Institute (NCI) grants U54CA143803, CA163124, CA093900, and CA143055, as well as by the Prostate Cancer Foundation and the Patrick C. Walsh Fund. The work of K.C.V. is supported by NCI grant F32CA206394. The authors are grateful to S. Amend for editing the manuscript.
Publisher Copyright:
© 2018 Macmillan Publishers Ltd., part of Springer Nature.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Cancers are not composed merely of cancer cells alone; instead, they are complex 'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma is a critical component of the tumour microenvironment, where it has crucial roles in tumour initiation, progression, and metastasis. Most anticancer therapies target cancer cells specifically, but the tumour stroma can promote the resistance of cancer cells to such therapies, eventually resulting in fatal disease. Therefore, novel treatment strategies should combine anticancer and antistromal agents. Herein, we provide an overview of the advances in understanding the complex cancer cell-Tumour stroma interactions and discuss how this knowledge can result in more effective therapeutic strategies, which might ultimately improve patient outcomes.
AB - Cancers are not composed merely of cancer cells alone; instead, they are complex 'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma is a critical component of the tumour microenvironment, where it has crucial roles in tumour initiation, progression, and metastasis. Most anticancer therapies target cancer cells specifically, but the tumour stroma can promote the resistance of cancer cells to such therapies, eventually resulting in fatal disease. Therefore, novel treatment strategies should combine anticancer and antistromal agents. Herein, we provide an overview of the advances in understanding the complex cancer cell-Tumour stroma interactions and discuss how this knowledge can result in more effective therapeutic strategies, which might ultimately improve patient outcomes.
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U2 - 10.1038/s41571-018-0007-1
DO - 10.1038/s41571-018-0007-1
M3 - Review article
C2 - 29651130
AN - SCOPUS:85045258115
SN - 1759-4774
VL - 15
SP - 366
EP - 381
JO - Nature Reviews Clinical Oncology
JF - Nature Reviews Clinical Oncology
IS - 6
ER -