Targeting the tumour stroma to improve cancer therapy

Kenneth C. Valkenburg, Amber E. De Groot, Kenneth J. Pienta

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancers are not composed merely of cancer cells alone; instead, they are complex 'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma is a critical component of the tumour microenvironment, where it has crucial roles in tumour initiation, progression, and metastasis. Most anticancer therapies target cancer cells specifically, but the tumour stroma can promote the resistance of cancer cells to such therapies, eventually resulting in fatal disease. Therefore, novel treatment strategies should combine anticancer and antistromal agents. Herein, we provide an overview of the advances in understanding the complex cancer cell-Tumour stroma interactions and discuss how this knowledge can result in more effective therapeutic strategies, which might ultimately improve patient outcomes.

Original languageEnglish (US)
Pages (from-to)366-381
Number of pages16
JournalNature Reviews Clinical Oncology
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2018

ASJC Scopus subject areas

  • Oncology

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