Targeting the neurovascular unit: Development of a new model and consideration for novel strategy for Alzheimer's disease

Rui Liu, Tian tai Zhang, Cai xia Wu, Xi Lan, Guan hua Du

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer's disease involves the complex and interconnected cascade of cellular and molecular events. Only a few treatments are available to slow the course of the disease at present. Recent studies suggest that neurovascular unit serves to maintain cerebral homeostasis, and pathological interactions between components of neurovascular unit lead to cerebral dysfunction. In present study, we established a functional unit trying to target major components of the neurovascular unit by the co-culture of rat cortical parenchymal culture and cerebral microvascular endothelial cells. This entity allowed the application of techniques such as immunofluorescent imaging and biological assays under defined conditions. The morphology of cell types, blood-brain barrier function and neuronal activation were investigated. The insight revealed that targeting components of the neurovascular unit, rather than just the neuron, might be a priority in Alzheimer's disease and more likely to provide cerebroprotection.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalBrain Research Bulletin
Volume86
Issue number1-2
DOIs
StatePublished - Aug 10 2011
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid β peptide
  • Blood-brain barrier
  • Cerebral microvascular endothelial cells
  • Neurovascular unit

ASJC Scopus subject areas

  • Neuroscience(all)

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