TY - JOUR
T1 - Targeting the epidermal growth factor receptor in non-small-cell lung cancer
T2 - Who, which, when, and how?
AU - Juergens, Rosalyn
AU - Brahmer, Julie
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2007/7
Y1 - 2007/7
N2 - Aberrations in the signaling cascade of the epidermal growth factor receptor are common to several solid tumors. Compounds aimed at targeting this pathway have been approved for use by the US Food and Drug Administration for lung, head and neck, pancreas, and colorectal carcinomas. Unfortunately, only the minority of patients treated with this class of agents will have responses or improvements in survival. This article reviews the data on agents that exploit tumor dependency on epidermal growth factor receptor cascade and describes the knowledge on how to discern the appropriate patient population for receiving these agents.
AB - Aberrations in the signaling cascade of the epidermal growth factor receptor are common to several solid tumors. Compounds aimed at targeting this pathway have been approved for use by the US Food and Drug Administration for lung, head and neck, pancreas, and colorectal carcinomas. Unfortunately, only the minority of patients treated with this class of agents will have responses or improvements in survival. This article reviews the data on agents that exploit tumor dependency on epidermal growth factor receptor cascade and describes the knowledge on how to discern the appropriate patient population for receiving these agents.
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U2 - 10.1007/s11912-007-0031-2
DO - 10.1007/s11912-007-0031-2
M3 - Review article
C2 - 17588349
AN - SCOPUS:34447272913
SN - 1523-3790
VL - 9
SP - 255
EP - 264
JO - Current oncology reports
JF - Current oncology reports
IS - 4
ER -