Targeting the aryl hydrocarbon receptor/polyamine biosynthesis axis of evil for cancer therapy

Research output: Contribution to journalReview article

Abstract

The polyamine metabolic pathway has been considered a rational target for antineoplastic therapy since it was discovered that polyamines are absolute requirements for tumor initiation, growth, and, in some instances, survival. Although several promising preclinical studies have demonstrated the critical nature of polyamines for tumor growth, the clinical success of agents targeting polyamine metabolism have been lacking. In the accompanying article, Bianchi-Smiraglia et al. identify both a new target and new drug that inhibits polyamine biosynthesis, reduces intracellular polyamines, and inhibits the growth of several models of human multiple myeloma. These results are both intriguing and provide promise for moving such a strategy to the clinic.

Original languageEnglish (US)
Pages (from-to)4254-4256
Number of pages3
JournalJournal of Clinical Investigation
Volume128
Issue number10
DOIs
StatePublished - Oct 1 2018

ASJC Scopus subject areas

  • Medicine(all)

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