@inbook{fce079044e484c179619a33ccacb2d4f,
title = "Targeting TCTP with sertraline and thioridazine in cancer treatment",
abstract = "We have initially demonstrated in knocking down experiments that decreasing TCTP in cancer cells leads in some tissues to cell death while in others to a complete reorganization of the tumor into architectural structures reminiscent of normal ones. Based on these experiments and a series of other findings confirming the key role of TCTP in cancer, it became important to find pharmacological compounds to inhibit its function, and this became for us a priority. In the present text, we explain in detail the experiments that were performed and the perspectives of sertraline in cancer treatment, as this became today a reality with a clinical study that started in collaboration with Columbia University and Johns Hopkins University.",
author = "Robert Amson and Christian Auclair and Fabrice Andr{\'e} and Judith Karp and Adam Telerman",
note = "Funding Information: Acknowledgements We thank Manale Karam for precious help. This work was supported by grants from the French National Agency for Research (ANR, ANR-09-BLAN-0292) to AT, RA, and MV; European Union Network of Excellence CONTICANET to AT and RA; LabEx LERMIT to AT and RA; INCa Projets libres de Recherche 2013-1-PL BIO-10 “Biologie et Sciences du Cancer” to AT and RA; Ligue Nationale Contre le Cancer to AT and RA; Odyssea fund to RA. Publisher Copyright: {\textcopyright} 2017, Springer International Publishing AG.",
year = "2017",
doi = "10.1007/978-3-319-67591-6_15",
language = "English (US)",
series = "Results and Problems in Cell Differentiation",
publisher = "Springer Verlag",
pages = "283--290",
booktitle = "Results and Problems in Cell Differentiation",
}