Targeting RNA helicases in cancer: The translation trap

Marise R. Heerma van Voss, Paul J. van Diest, Venu Raman

Research output: Contribution to journalReview article

Abstract

Cancer cells are reliant on the cellular translational machinery for both global elevation of protein synthesis and the translation of specific mRNAs that promote tumor cell survival. Targeting translational control in cancer is therefore increasingly recognized as a promising therapeutic strategy. In this regard, DEAD/H box RNA helicases are a very interesting group of proteins, with several family members regulating mRNA translation in cancer cells. In this review, we delineate the mechanisms by which DEAD/H box proteins modulate oncogenic translation and how inhibition of these RNA helicases can be exploited for anti-cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)510-520
Number of pages11
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1868
Issue number2
DOIs
StatePublished - Dec 1 2017

Keywords

  • DDX
  • DDX3
  • eIF4A
  • RNA helicase
  • Translation

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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