Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

Robert A. Casero, Laurence J. Marton

Research output: Contribution to journalReview articlepeer-review

Abstract

The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development.

Original languageEnglish (US)
Pages (from-to)373-390
Number of pages18
JournalNature Reviews Drug Discovery
Volume6
Issue number5
DOIs
StatePublished - May 2007

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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