Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate

Shridhar Bhat, Andrew R. Vaino, Walter A. Szarek

Research output: Contribution to journalArticlepeer-review

Abstract

As part of continuing studies on drug delivery to the human liver, a phosphonoacetate-trilactoside conjugate (12) has been synthesized in an overall yield of 23%. The shortness of the synthesis of this conjugate hinges upon a successful Michaelis-Arbuzov reaction of bromoacetamide 8 with tris-(trimethylsilyl) phosphite.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalIsrael Journal of Chemistry
Volume40
Issue number3-4
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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