Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate

Shridhar Bhat; Andrew R. Vaino; Walter A. Szarek

doi:10.1560/8QKA-DFYF-FJ70-E1CX

Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate

Shridhar Bhat, Andrew R. Vaino, Walter A. Szarek

Research output: Contribution to journal › Article › peer-review

Abstract

As part of continuing studies on drug delivery to the human liver, a phosphonoacetate-trilactoside conjugate (12) has been synthesized in an overall yield of 23%. The shortness of the synthesis of this conjugate hinges upon a successful Michaelis-Arbuzov reaction of bromoacetamide 8 with tris-(trimethylsilyl) phosphite.

Original language	English (US)
Pages (from-to)	335-341
Number of pages	7
Journal	Israel Journal of Chemistry
Volume	40
Issue number	3-4
DOIs	https://doi.org/10.1560/8QKA-DFYF-FJ70-E1CX
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1560/8QKA-DFYF-FJ70-E1CX

Fingerprint Dive into the research topics of 'Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate'. Together they form a unique fingerprint.

Cite this

@article{897186f9398b4ef0abc88c8dab02015a,

title = "Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate",

abstract = "As part of continuing studies on drug delivery to the human liver, a phosphonoacetate-trilactoside conjugate (12) has been synthesized in an overall yield of 23%. The shortness of the synthesis of this conjugate hinges upon a successful Michaelis-Arbuzov reaction of bromoacetamide 8 with tris-(trimethylsilyl) phosphite.",

author = "Shridhar Bhat and Vaino, {Andrew R.} and Szarek, {Walter A.}",

year = "2000",

doi = "10.1560/8QKA-DFYF-FJ70-E1CX",

language = "English (US)",

volume = "40",

pages = "335--341",

journal = "Israel Journal of Chemistry",

issn = "0021-2148",

publisher = "Wiley-VCH Verlag",

number = "3-4",

}

TY - JOUR

T1 - Targeting of phosphonoacetate to the liver

T2 - Synthesis of a phosphonoacetate-trilactoside conjugate

AU - Bhat, Shridhar

AU - Vaino, Andrew R.

AU - Szarek, Walter A.

PY - 2000

Y1 - 2000

N2 - As part of continuing studies on drug delivery to the human liver, a phosphonoacetate-trilactoside conjugate (12) has been synthesized in an overall yield of 23%. The shortness of the synthesis of this conjugate hinges upon a successful Michaelis-Arbuzov reaction of bromoacetamide 8 with tris-(trimethylsilyl) phosphite.

AB - As part of continuing studies on drug delivery to the human liver, a phosphonoacetate-trilactoside conjugate (12) has been synthesized in an overall yield of 23%. The shortness of the synthesis of this conjugate hinges upon a successful Michaelis-Arbuzov reaction of bromoacetamide 8 with tris-(trimethylsilyl) phosphite.

UR - http://www.scopus.com/inward/record.url?scp=0034562223&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034562223&partnerID=8YFLogxK

U2 - 10.1560/8QKA-DFYF-FJ70-E1CX

DO - 10.1560/8QKA-DFYF-FJ70-E1CX

M3 - Article

AN - SCOPUS:0034562223

VL - 40

SP - 335

EP - 341

JO - Israel Journal of Chemistry

JF - Israel Journal of Chemistry

SN - 0021-2148

IS - 3-4

ER -