Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate

Shridhar Bhat; Andrew R. Vaino; Walter A. Szarek

doi:10.1560/8QKA-DFYF-FJ70-E1CX

Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate

Shridhar Bhat, Andrew R. Vaino, Walter A. Szarek

Research output: Contribution to journal › Article › peer-review

Abstract

As part of continuing studies on drug delivery to the human liver, a phosphonoacetate-trilactoside conjugate (12) has been synthesized in an overall yield of 23%. The shortness of the synthesis of this conjugate hinges upon a successful Michaelis-Arbuzov reaction of bromoacetamide 8 with tris-(trimethylsilyl) phosphite.

Original language	English (US)
Pages (from-to)	335-341
Number of pages	7
Journal	Israel Journal of Chemistry
Volume	40
Issue number	3-4
DOIs	https://doi.org/10.1560/8QKA-DFYF-FJ70-E1CX
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1560/8QKA-DFYF-FJ70-E1CX

Cite this

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title = "Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate",

abstract = "As part of continuing studies on drug delivery to the human liver, a phosphonoacetate-trilactoside conjugate (12) has been synthesized in an overall yield of 23%. The shortness of the synthesis of this conjugate hinges upon a successful Michaelis-Arbuzov reaction of bromoacetamide 8 with tris-(trimethylsilyl) phosphite.",

author = "Shridhar Bhat and Vaino, {Andrew R.} and Szarek, {Walter A.}",

year = "2000",

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AU - Szarek, Walter A.

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AB - As part of continuing studies on drug delivery to the human liver, a phosphonoacetate-trilactoside conjugate (12) has been synthesized in an overall yield of 23%. The shortness of the synthesis of this conjugate hinges upon a successful Michaelis-Arbuzov reaction of bromoacetamide 8 with tris-(trimethylsilyl) phosphite.

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Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate

Abstract

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