Targeting mTOR for cancer treatment

Belen Rubio-Viqueira, Manuel Hidalgo

Research output: Contribution to journalReview article

Abstract

The mammalian target of rapamycin (mTOR) is involved in the control of cellular growth and proliferation. Abnormal activation of signaling pathways both proximal and distal to this kinase occurs frequently in human cancer, suggesting that mTOR is an attractive target for antineoplastic therapies. Rapamycin and its analogs inhibit mTOR and have demonstrated potent antitumor activity in vitro and in xenograft models. Several phase I and phase II clinical studies with rapamycin-like drugs have been conducted and have demonstrated antitumor activity in various types of refractory neoplasms. To date, mTOR inhibitors have been well tolerated at a wide range of doses, making the selection of phase II trial doses based solely on toxicity criteria difficult. Assessment of the pharmacodynamic effects in surrogate tumor tissues has been used to determine the pharmacodynamically active doses. The lack of a parallel assessment of tumor tissue effects coupled with the intrinsically high interpatient variability has limited the value of these studies. A better understanding of markers that are predictive of response to mTOR inhibitors could be used for improved patient selection in clinical trials. mTOR inhibitors are promising anticancer agents; however, further studies are required to advance these drugs into the clinic. This review will describe the mTOR pathway and highlight its role as a potential drug target. Several mTOR inhibitors that are currently undergoing clinical development, and the challenges facing the development of inhibitors of this type, will also be discussed.

Original languageEnglish (US)
Pages (from-to)501-512
Number of pages12
JournalCurrent Opinion in Investigational Drugs
Volume7
Issue number6
StatePublished - Jun 1 2006

Keywords

  • AP-23573
  • Everolimus
  • Rapamycin
  • Targeted therapy
  • Temsirolimus
  • mTOR

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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  • Cite this

    Rubio-Viqueira, B., & Hidalgo, M. (2006). Targeting mTOR for cancer treatment. Current Opinion in Investigational Drugs, 7(6), 501-512.